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Advanced Neurology EPAC2 null leads to tauopathy
Conflict of interest BMB Rep, 54(3): 149–156.
The authors have no conflicts of interest to declare. https://doi.org/10.5483/BMBRep.2021.54.3.233
10. Zhang X, Huang X, Fang C, et al., 2017, miR-124 Regulates
Author contributions the Expression of BACE1 in the Hippocampus Under
Conceptualization: Ling-Qiang Zhu Chronic Cerebral Hypoperfusion. Mol Neurobiol, 54(4):
2498–24506.
Methodology: De-Yi Liu, He-Zhou Huang, Ke Li
https://doi.org/10.1007/s12035-016-9845-y
Resources: De-Yi Liu, He-Zhou Huang, Ke Li 11. Ittner A, Ittner LM, 2018, Dendritic Tau in Alzheimer’s
Investigation: De-Yi Liu, He-Zhou Huang, Ke Li Disease. Neuron, 99(1): 13-27.
Formal analysis: De-Yi Liu, Youming Lu, Ling-Qiang Zhu https://doi.org/10.1016/j.neuron.2018.06.003
Writing – original draft: De-Yi Liu, Ling-Qiang Zhu 12. Zaldua N, Gastineau M, Hoshino M, et al., 2007, Epac
signaling pathway involves STEF, a guanine nucleotide
Writing – review & editing: Ling-Qiang Zhu exchange factor for Rac, to regulate APP processing. FEBS
Lett, 581(30): 5814-5818.
References
https://doi.org/10.1016/j.febslet.2007.11.053
1. Gong CX, Liu F, Grundke-Iqbal I, Iqbal K, 2005, Post- rd
translational modifications of tau protein in Alzheimer’s 13. Robichaux WG 3 , Cheng X, 2018, Intracellular cAMP
disease. J Neural Transm (Vienna), 112(6): 813–838. sensor EPAC: Physiology, pathophysiology, and therapeutics
development. Physiol Rev, 98(2): 919-1053.
https://doi.org/10.1007/s00702-004-0221-0
https://doi.org/10.1152/physrev.00025.2017
2. Mandelkow E, 1999, Alzheimer’s disease. The tangled tale of
tau. Nature, 402(6762): 588–589. 14. Kimura T, Ishiguro K, Hisanaga S, 2014, Physiological and
pathological phosphorylation of tau by Cdk5. Front Mol
https://doi.org/10.1038/45095 Neurosci, 7: 65.
3. Iqbal K, Liu F, Gong CX, 2016, Tau and neurodegenerative https://doi.org/10.3389/fnmol.2014.00065
disease: The story so far. Nat Rev Neurol, 12(1):15-27.
15. Partrick GN, Zukerberg L, Nikolic, M, et al., 1999,
https://doi.org/10.1038/nrneurol.2015.225 Conversion of p35 to p25 deregulates Cdk5 activity and
4. de Rooij J, Zwartkruis FJ, Verheijen MH, et al., (1998) Epac promotes neurodegeneration. Nature, 402(6762): 615–622.
is a Rap1 guanine-nucleotide-exchange factor directly https://doi.org/10.1038/35081149
activated by cyclic AMP. Nature, 396(6710): 474–477.
16. Utreras E, Henriquez D, Contreras-Vallejos E, et al.,
https://doi.org/10.1038/24884 2013, Cdk5 regulates Rap1 activity. Neurochem Int, 62(6):
848–853.
5. Zhang CL, Katoh M, Shibasaki T, et al., 2009, The cAMP
sensor 2 is a direct tartget of antidiabetic sulfonylurea drugs. https://doi.org/10.1016/j.neuint.2013.02.011
Science, 325(5940): 607–610.
17. Liu J, Yang J, Xu Y, et al., 2017, Roscovitine, a CDK5 inhibitor,
https://doi.org/10.1126/science.1172256 alleviates sevoflurane-induced cognitive dysfunction via
6. Yang Y, Shu X, Liu D, et al., 2012, EPAC null mutation impairs regulation tau/GSK3beta and ERK/PPARgamma/CREB
learning and social interactions via aberrant regulation of signaling. Cell Physiol Biochem, 44(2): 423–435.
miR-124 and Zif268 translation. Neuron, 73(4): 774–788. https://doi.org/10.1159/000485008
https://doi.org/10.1016/j.neuron.2012.02.003 18. Kitagawa S, 2019, Experimental manipulation of calpain
7. Zhou L, Ma SL, Yeung PK, et al., 2016, Anxiety and activity in vitro. Methods Mol Biol, 1915: 209–218.
depression with neurogenesis defects in exchange protein https://doi.org/10.1007/978-1-4939-8988-1_16
directly activated by cAMP 2-deficient mice are ameliorated 19. Fujita H, Kato T, Watanabe N, et al., 2011, Calpain inhibitors
by a selective serotonin reuptake inhibitor, Prozac. Transl stimulate phagocyte functions via activation of human
Psychiatry, 6(9): e881.
formyl peptide receptors. Arch Biochem Biophys, 513(1):
https://doi.org/10.1038/tp.2016.129 51–60.
8. Mcphee I, Gibson L, Kewney J, et al., 2005, Cyclic nucleotide https://doi.org/10.1016/j.abb.2011.06.007
signalling: A molecular approach to drug discovery for 20. Li K, Liu FF, He CX, et al., 2016, Olfactory deprivation hastens
Alzheimer’s disease. Biochem Soc Trans, 33(6): 1330–1332.
alzheimer-like pathologies in a human tau-overexpressed
9. Lee K, 2021, Epac: New emerging cAMP-binding protein. mouse model via activation of cdk5. Mol Neurobiol, 53(1):
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