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Advanced Neurology Role of Panax ginseng in neuronal complications

Table 1. The retrieved 66 chemical compounds in Panax ginseng
ID Compound Mol Wt OB (%) DL ID Compound Mol Wt OB (%) DL
5318 Dianthramine 289.26 40.45 0.20 4100 N-Salicylidene-salicylamine 227.28 95.46 0.11
1641 Methyl linoleate 294.53 41.93 0.17 422 kaempferol 286.25 41.88 0.24
1818 Methyl palmitelaidate 268.49 34.61 0.12 4492 Chrysanthemaxanthin 584.96 38.72 0.58
1965 Dauricine (8CI) 624.84 23.65 0.37 4498 12-O-Nicotinoylisolineolone 469.63 20.70 0.83
2307 20-Hexadecanoylingenol 586.94 28.20 0.68 5269 (+)-Maalioxide 222.41 55.93 0.13
2669 Campesteryl ferulate 576.94 22.10 0.59 5272 13-Tetradecenyl acetate 254.46 36.76 0.10
2879 Diop 390.62 43.59 0.39 5280 ginsenoside-Rh1_qt 476.82 20.13 0.78
449 Stigmasterol 412.77 43.83 0.76 5282 20(S)-Ginsenoside-Rh1_qt 476.82 20.13 0.78
358 Beta-sitosterol 414.79 36.91 0.75 5285 20(s)-protopanaxadiol 460.82 29.69 0.77
3648 Inermin 284.28 65.83 0.54 5288 20-(S)-Ginsenoside-Rg3_qt 460.82 29.69 0.77
5364 Malonylginsenoside Rd_qt 460.82 29.69 0.77 5292 3-O-beta-D-Glucuronopyranosyl gypsogenin_qt 470.76 23.72 0.75
3902 Methyl (Z)-icos-11-enoate 324.61 29.49 0.23 5301 6’-Malonylginsenoside Rd1_qt1 460.82 29.69 0.77
5302 7-(beta-Xylosyl) 962.15 27.33 0.17 5396 cis-Widdrol alpha-epoxide 238.41 69.04 0.15
cephalomannine
5305 Nepetin 316.28 26.75 0.31 5319 Ditertbutyl phthalate 278.38 43.67 0.13
5308 Aposiopolamine 271.34 66.65 0.22 5320 arachidonate 304.52 45.57 0.20
5314 Celabenzine 379.55 101.88 0.49 5321 Frutinone A 264.24 65.90 0.34
5317 Deoxyharringtonine 515.66 39.27 0.81 5327 Gypnoside V_qt 460.82 29.69 0.77
5343 Ginsenoside-Rg3_qt 460.82 29.69 0.77 5353 Ginsenoyne C 276.41 43.38 0.13
5344 Ginsenoside rh2 622.98 36.32 0.56 5355 Ginsenoyne E 258.39 36.53 0.13
5348 Ginsenoside-Rh4_qt 458.80 31.11 0.78 5356 Girinimbin 263.36 61.22 0.31
5351 Ginsenoyne A 258.39 66.22 0.13 5357 Gomisin B 514.62 31.99 0.83
5352 Ginsenoyne B 294.85 39.79 0.13 5360 malkangunin 432.56 57.71 0.63
5376 Panaxadiol 460.82 33.09 0.79 5373 notoginsenoside R2_qt 476.82 20.13 0.78
3845 Folinic acid 473.50 23.60 0.74 5362 Malonylginsenoside Rc_qt1 460.82 29.69 0.77
5366 Malvic acid 280.50 30.99 0.15 5401 ginsenoside Rg5_qt 442.80 39.56 0.79
5378 Panaxytriol 278.43 33.76 0.13 628 darutoside 574.93 21.32 0.63
5384 Suchilactone 368.41 57.52 0.56 66 alloaromadedrene 204.39 53.46 0.10
5386 Vulgarin 264.35 29.21 0.20 676 DBP 278.38 64.54 0.13
749 Linoleic 280.50 41.90 0.14 1312 9-Hexadecenoic acid 254.46 35.78 0.10
5398 Alexandrine 576.95 20.63 0.63 787 Fumarine 353.40 59.26 0.83
5399 Alexandrin_qt 414.79 36.91 0.75 935 Hepanal 204.39 53.83 0.10
Mol Wt, molecular weight; OB, oral bioavailaity; DL, drug likeliness; ID, identity document

of four protein targets, with a medium network probability node degree and clustering coefficient were found to be 2
score of 0.400, with four nodes and four edges. The and 0.833, respectively. Moreover, three hubs were found
resultant PPI network comprises functional interactions, due to their nodal degree being higher than the average,
where the nodes and edges represented the target proteins that is, 2, where CYP1A2 was found to have the highest
and/or their associated genes, and the interactions between node degree, that is, 9. Table 2 describes the functional
different genes, respectively. Details of the constructed enrichments in PPIN network (KEGG Pathways). It was
network show that its P-value is small (0.271), whereas followed by other proteins, such as GSTP1, MAPK8, and
the number of edges for the network was found to be 3 GSTT1, respectively. These proteins and associated hubs
at randomly chosen nodes. Small P-value denotes the are reported to be significant mediators in depression.
non-random selection and the significant number of The action view of the functional nodes is shown in
edges in a network. In this PPI network, the values for Figure 2, demonstrating the functions of these proteins,

Volume 1 Issue 2 (2022) 4 https://doi.org/10.36922/an.v1i2.44