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Advanced Neurology Role of Panax ginseng in neuronal complications

Table 4. Docking scores of various compounds with Table 5. Docking outcomes of various compounds with
disease‑related proteins. disease‑related proteins.
Receptor Ligand Docking H‑bonds H‑bonds Receptor Ligand
score GSTP1
GSTP1 Gensinside −7.63 5 GLU97, GLN64,
GLY50, LYS44, and
GLN50
Panaxydol −6.10 2 ASN204 and
TYR108 Gensinside Panaxydol
Panaxynol −5.78 1 PRO53
Panaxytriol −6.12 3 LEU52, TYR7, and
PRO53
HSP90 Gensinside −7.15 2 GLN212 and LYS208
Panaxydol −7.45 2 TRP162 and GLY135 Panaxynol Panaxytriol
Panaxynol −7.79 1 GLY35 HSP90
Panaxytriol −7.21 3 GLY135, PHE138,
and LEU103
MAPK8 Gensinside −8.00 4 ARG72, ILE148,
GLY146, and
PRO335
Gensinside Panaxydol
Panaxydol −4.76 3 ILE304, ASP305, and
LYS308
Panaxynol −4.93 1 GLN117
Panaxytriol −4.37 2 MET111 and SER34

Panaxynol Panaxytriol
Nevertheless, the latter part remains to be confirmed, MAPK8
while the former has been subject to refutation.
Polymorphisms in the encoding gene have been heavily
associated with the manifestation of several forms and
types of neurodegenerative cells [45,46] . This function of the
protein/enzyme has revealed a metabolic pathway that Gensinside Panaxydol
was observed to cause neurodegeneration, with various
members of the CYP protein family playing a significant
part in the activation of different carcinogenic compounds,
which can then contribute to the polymorphisms in the
[47]
genes, resulting in neurodegenerative cells . Elevated Panaxynol Panaxytriol
levels of CYP1A2 have been reported to be associated with
increased risk for many types of neurodegenerations ,
[48]
with its gene polymorphisms altering its expression that
subsequently influence the activation and suppression of
signaling pathways . GSTP1 is a protein that has been
[49]
reported to play an important role in the proliferation
of cells by the action of inhibiting JNK activity, which is
observed to be inversely associated with GSTP1 activity,
thus linking it significantly with the development of
neurodegenerative cells in tissues. In patients with
neuronal damage, the production of GSTP1 is increased.
GSTP1 reportedly targets its production, thereby acting
as a GSTP1 target gene, associating the activity of GSTP1 Figure 4. Docking-generated complexes of proteins mitogen-activated
in neurodegenerative as well as healthy cells in vitro [50,51] . protein kinases-8 bonded to gensinside.

Volume 1 Issue 2 (2022) 7 https://doi.org/10.36922/an.v1i2.44