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Advanced Neurology Role of Panax ginseng in neuronal complications

Table 3. Retrieval of GO terms and their related genes through ClueGO
GO ID GO term Term P value (¤) Group P value (¤) Associated genes
43507 Positive regulation of JUN kinase 3.38×10 (3.71×10 ) 3.38×10 (1.01×10 ) AGER, BIRC7, MAP3K2, MAP3K5,
−11
−11
−10
−10
activity MAP3K7, PTPN1, TNF, TRAF6
61077 Chaperone-mediated protein folding 1.10×10 (1.10×10 ) 1.10×10 (1.10×10 ) CD74, DNAJB2, FKBP6
−03
−3
−3
−3
70423 Nucleotide-binding oligomerization 3.99×10 (5.98×10 ) 1.62×10 (6.47×10 ) BIRC3, IKBKB, IKBKG, MAP3K7, TAB1,
−18
−17
−19
−19
domain containing signaling pathway TLR4, TRAF6, UBE2N, UBE2V1, XIAP
−7
−7
−7
2755 MyD88-dependent toll-like receptor 9.18×10 (8.26×10 ) 4.33×10 (8.67×10 ) MAP3K7, MYD88, TAB1, TLR4, TRAF6
−8
signaling pathway
Corrected with Bonferroni correction using a step-down procedure

Figure 3. Retrieval of functionally grouped networks for the candidate targets of Panax ginseng, obtained through ClueGO, with terms as nodes associated.
Each group is represented by only the label of the most significant term. The node size indicates the term enrichment significance. Functionally associated
groups partially overlap.

apoptosis was not observed but LC3-II levels were found proteins, namely, 1A1, 1A2, and 1B1, which reside in
to be elevated . human tissues and serve a key role in the development of
[39]
neurodegeneration and the growth of neurodegeneratice
In PPIN, the main protein hubs were found to be cells . Much of the expression of the CYP1 family is
[41]
CYP1A2, GSTP1, MAPK8, and GSTT1, which have mediated by the AhR signaling pathway, which can
already been reported to be involved in the development, result in the dysfunction of the estrogen homeostasis,
and regulation (positive or negative) of neuronal leading to neurodegeneration [42,43] . CYP1A2 is one of
damage. The role of the cytochrome family P450 has the important CYP proteins, which is attributable to the
been well-reported, as it is primarily involved in major action of carcinogens. It was previously believed that the
cell functions, particularly in the transportation of expression of the CYP1A2 gene largely existed in the liver
electrons . The CYP1 family includes three fundamental and was inducible by major environmental stimuli .
[40]
[44]
Volume 1 Issue 2 (2022) 6 https://doi.org/10.36922/an.v1i2.44