Page 81 - AN-2-2
P. 81
Advanced Neurology Role of immunosuppressants in autism
75. Zhang YQ, Lin WP, Huang LP, et al., 2021, Dopamine D2 https://doi.org/10.3389/fnsyn.2010.00136
receptor regulates cortical synaptic pruning in rodents. Nat 88. Yin J, Valin KL, Dixon ML, et al., 2017, The role of microglia
Commun, 12: 6444.
and macrophages in CNS homeostasis, autoimmunity, and
https://doi.org/10.1038/s41467-021-26769-9 cancer. J Immunol Res, 2017: 5150678.
76. Zajicek AS, Ruan H, Dai H, et al., 2022, Cylindromatosis https://doi.org/10.1155/2017/5150678
drives synapse pruning and weakening by promoting 89. Onore C, Careaga M, Ashwood P, 2012, The role of immune
macroautophagy through Akt-mTOR signaling. Mol dysfunction in the pathophysiology of autism. Brain Behav
Psychiatry, 27: 2414–2424.
Immun, 26: 383–392.
https://doi.org/10.1038/s41380-022-01571-1
https://doi.org/10.1016/j.bbi.2011.08.007
77. Kelleher RJ, Bear MF, 2008, The autistic neuron: Troubled 90. Penzes P, Cahill ME, Jones KA, et al., 2011, Dendritic spine
translation? Cell, 135: 401–406. pathology in neuropsychiatric disorders. Nat Neurosci,
https://doi.org/10.1016/j.cell.2008.10.017 14: 285–293.
78. Kim HJ, Cho MH, Shim WH, et al., 2017, Deficient https://doi.org/10.1038/nn.2741
autophagy in microglia impairs synaptic pruning and causes 91. Masi A, Glozier N, Dale R, et al., 2017, The immune system,
social behavioral defects. Mol Psychiatry, 22: 1576–1584.
cytokines, and biomarkers in autism spectrum disorder.
https://doi.org/10.1038/mp.2016.103 Neurosci Bull, 33: 194–204.
79. Ma T, Hoeffer CA, Capetillo-Zarate E, et al., Dysregulation https://doi.org/10.1007/s12264-017-0103-8
of the mTOR pathway mediates impairment of synaptic 92. Gibney SM, Drexhage HA, 2013, Evidence for a dysregulated
plasticity in a mouse model of Alzheimer’s disease. PLoS immune system in the etiology of psychiatric disorders.
One, 5: e12845.
J Neuroimmune Pharmacol, 8: 900–920.
https://doi.org/10.1371/journal.pone.0012845
https://doi.org/10.1007/s11481-013-9462-8
80. Meng XF, Yu JT, Song JH, et al., 2013, Role of the mTOR 93. Vojdani A, Mumper E, Granpeesheh D, et al., 2008, Low
signaling pathway in epilepsy. J Neurol Sci, 332: 4–15.
natural killer cell cytotoxic activity in autism: The role of
81. Trowsdale J, Barten R, Haude A, et al., 2001, The genomic glutathione, IL-2 and IL-15. J Neuroimmunol, 205: 148–154.
context of natural killer receptor extended gene families. https://doi.org/10.1016/j.jneuroim.2008.09.005
Immunol Rev, 181: 20–38.
94. Siniscalco D, Mijatovic T, Bosmans E, et al., 2016, Decreased
https://doi.org/10.1034/j.1600-065x.2001.1810102.x
numbers of CD57+CD3- cells identify potential innate
82. Patterson PH, 2011, Maternal infection and immune immune differences in patients with autism spectrum
involvement in autism. Trends Mol Med, 17: 389–394. disorder. In vivo, 30: 83–89.
https://doi.org/10.1016/j.molmed.2011.03.001 95. Bjørklund G, Meguid NA, El-Bana MA, et al., 2020,
Oxidative stress in autism spectrum disorder. Mol Neurobiol,
83. Enstrom AM, Lit L, Onore CE, et al., 2009, Altered gene
expression and function of peripheral blood natural killer cells 57: 2314–2332.
in children with autism. Brain Behav Immun, 23: 124–133. 96. Matelski L, Van de Water J, 2016, Risk factors in autism:
Thinking outside the brain. J Autoimmun, 67: 1–7.
https://doi.org/10.1016/j.bbi.2008.08.001
https://doi.org/10.1016/j.jaut.2015.11.003
84. Torres AR, Westover JB, Gibbons C, et al., 2012, Activating
killer-cell immunoglobulin-like receptors (KIR) and their 97. Yirmiya R, Goshen I, 2011, Immune modulation of learning,
cognate HLA ligands are significantly increased in autism. memory, neural plasticity and neurogenesis. Brain Behav
Brain Behav Immun, 26: 1122–1127. Immun, 25: 181–213.
https://doi.org/10.1016/j.bbi.2012.07.014 https://doi.org/10.1016/j.bbi.2010.10.015
85. Blanco K, Radoff GP, 2007, Lyme disease and autism a new 98. Zou R, Xu F, Wang Y, et al., 2020, Changes in the gut
paradigm. Townsend letter: Exam Alternat Med, 285: 78–82. microbiota of children with autism spectrum disorder.
Autism Res, 13: 1614–1625.
86. Boulanger LM, 2009, Immune proteins in brain development
and synaptic plasticity. Neuron, 64: 93–109. https://doi.org/10.1002/aur.2358
https://doi.org/10.1016/j.neuron.2009.09.001 99. Mulle JG, Sharp WG, Cubells JF, 2013, The gut microbiome:
A new frontier in autism research. Curr Psychiatry Rep,
87. Garay PA, McAllister AK, 2010, Novel roles for immune
molecules in neural development: implications for 15: 337.
neurodevelopmental disorders. Front Synaptic Neurosci, 2: 136. https://doi.org/10.1007/s11920-012-0337-0
Volume 2 Issue 2 (2023) 21 https://doi.org/10.36922/an.391

