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Advanced Neurology                                                    Role of immunosuppressants in autism



            75.  Zhang YQ, Lin WP, Huang LP, et al., 2021, Dopamine D2      https://doi.org/10.3389/fnsyn.2010.00136
               receptor regulates cortical synaptic pruning in rodents. Nat   88.  Yin J, Valin KL, Dixon ML, et al., 2017, The role of microglia
               Commun, 12: 6444.
                                                                  and macrophages in CNS homeostasis, autoimmunity, and
               https://doi.org/10.1038/s41467-021-26769-9         cancer. J Immunol Res, 2017: 5150678.
            76.  Zajicek AS, Ruan H, Dai H, et al., 2022, Cylindromatosis      https://doi.org/10.1155/2017/5150678
               drives synapse pruning and weakening by promoting   89.  Onore C, Careaga M, Ashwood P, 2012, The role of immune
               macroautophagy through Akt-mTOR signaling.  Mol    dysfunction in the pathophysiology of autism. Brain Behav
               Psychiatry, 27: 2414–2424.
                                                                  Immun, 26: 383–392.
               https://doi.org/10.1038/s41380-022-01571-1
                                                                  https://doi.org/10.1016/j.bbi.2011.08.007
            77.  Kelleher RJ, Bear MF, 2008, The autistic neuron: Troubled   90.  Penzes P, Cahill ME, Jones KA, et al., 2011, Dendritic spine
               translation? Cell, 135: 401–406.                   pathology in neuropsychiatric disorders. Nat Neurosci,
               https://doi.org/10.1016/j.cell.2008.10.017         14: 285–293.
            78.  Kim  HJ, Cho MH,  Shim  WH,  et al., 2017,  Deficient      https://doi.org/10.1038/nn.2741
               autophagy in microglia impairs synaptic pruning and causes   91.  Masi A, Glozier N, Dale R, et al., 2017, The immune system,
               social behavioral defects. Mol Psychiatry, 22: 1576–1584.
                                                                  cytokines, and  biomarkers in  autism  spectrum  disorder.
               https://doi.org/10.1038/mp.2016.103                Neurosci Bull, 33: 194–204.
            79.  Ma T, Hoeffer CA, Capetillo-Zarate E, et al., Dysregulation      https://doi.org/10.1007/s12264-017-0103-8
               of the mTOR pathway mediates impairment of synaptic   92.  Gibney SM, Drexhage HA, 2013, Evidence for a dysregulated
               plasticity in a mouse model of Alzheimer’s disease.  PLoS   immune system in the etiology of psychiatric disorders.
               One, 5: e12845.
                                                                  J Neuroimmune Pharmacol, 8: 900–920.
               https://doi.org/10.1371/journal.pone.0012845
                                                                  https://doi.org/10.1007/s11481-013-9462-8
            80.  Meng XF, Yu JT, Song JH, et al., 2013, Role of the mTOR   93.  Vojdani A, Mumper E, Granpeesheh D,  et al., 2008, Low
               signaling pathway in epilepsy. J Neurol Sci, 332: 4–15.
                                                                  natural killer cell cytotoxic activity in autism: The role of
            81.  Trowsdale J, Barten R, Haude A, et al., 2001, The genomic   glutathione, IL-2 and IL-15. J Neuroimmunol, 205: 148–154.
               context of natural killer receptor extended gene families.      https://doi.org/10.1016/j.jneuroim.2008.09.005
               Immunol Rev, 181: 20–38.
                                                               94.  Siniscalco D, Mijatovic T, Bosmans E, et al., 2016, Decreased
               https://doi.org/10.1034/j.1600-065x.2001.1810102.x
                                                                  numbers of  CD57+CD3-  cells  identify  potential  innate
            82.  Patterson PH,  2011, Maternal infection  and immune   immune differences in patients with autism spectrum
               involvement in autism. Trends Mol Med, 17: 389–394.   disorder. In vivo, 30: 83–89.
               https://doi.org/10.1016/j.molmed.2011.03.001    95.  Bjørklund G, Meguid NA, El-Bana MA,  et al., 2020,
                                                                  Oxidative stress in autism spectrum disorder. Mol Neurobiol,
            83.  Enstrom AM, Lit L, Onore CE,  et al., 2009, Altered gene
               expression and function of peripheral blood natural killer cells   57: 2314–2332.
               in children with autism. Brain Behav Immun, 23: 124–133.   96.  Matelski L, Van de Water J, 2016, Risk factors in autism:
                                                                  Thinking outside the brain. J Autoimmun, 67: 1–7.
               https://doi.org/10.1016/j.bbi.2008.08.001
                                                                  https://doi.org/10.1016/j.jaut.2015.11.003
            84.  Torres AR, Westover JB, Gibbons C, et al., 2012, Activating
               killer-cell immunoglobulin-like receptors (KIR) and their   97.  Yirmiya R, Goshen I, 2011, Immune modulation of learning,
               cognate HLA ligands are significantly increased in autism.   memory, neural plasticity and neurogenesis.  Brain Behav
               Brain Behav Immun, 26: 1122–1127.                  Immun, 25: 181–213.
               https://doi.org/10.1016/j.bbi.2012.07.014          https://doi.org/10.1016/j.bbi.2010.10.015
            85.  Blanco K, Radoff GP, 2007, Lyme disease and autism a new   98.  Zou R, Xu F, Wang Y,  et al., 2020, Changes in the gut
               paradigm. Townsend letter: Exam Alternat Med, 285: 78–82.  microbiota of children with autism spectrum disorder.
                                                                  Autism Res, 13: 1614–1625.
            86.  Boulanger LM, 2009, Immune proteins in brain development
               and synaptic plasticity. Neuron, 64: 93–109.       https://doi.org/10.1002/aur.2358
               https://doi.org/10.1016/j.neuron.2009.09.001    99.  Mulle JG, Sharp WG, Cubells JF, 2013, The gut microbiome:
                                                                  A  new frontier in autism research.  Curr Psychiatry Rep,
            87.  Garay PA, McAllister AK, 2010, Novel roles for immune
               molecules in neural development: implications for   15: 337.
               neurodevelopmental disorders. Front Synaptic Neurosci, 2: 136.      https://doi.org/10.1007/s11920-012-0337-0


            Volume 2 Issue 2 (2023)                         21                         https://doi.org/10.36922/an.391
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