Page 80 - AN-2-2

Advanced Neurology Role of immunosuppressants in autism

https://doi.org/10.1016/j.jneuroim.2004.10.008 https://doi.org/10.1172/jci200317622
53. Meyer U, Feldon J, Schedlowski M, et al., 2005, Towards an 64. Tracey KJ, Wei H, Manogue KR, et al., 1988, Cachectin/
immuno-precipitated neurodevelopmental animal model of tumor necrosis factor induces cachexia, anemia, and
schizophrenia. Neurosci Biobehav Rev, 29: 913–947. inflammation. J Exp Med, 167: 1211–12127.
https://doi.org/10.1016/j.neubiorev.2004.10.012 https://doi.org/10.1084/jem.167.3.1211
54. Urakubo A, Jarskog LF, Lieberman JA, et al., 2001, Prenatal 65. Glantz LA, Gilmore JH, Lieberman JA, et al., 2006, Apoptotic
exposure to maternal infection alters cytokine expression in mechanisms and the synaptic pathology of schizophrenia.
the placenta, amniotic fluid, and fetal brain. Schizophr Res, Schizophr Res, 81: 47–63.
47: 27–36.
https://doi.org/10.1016/j.schres.2005.08.014
https://doi.org/10.1016/s0920-9964(00)00032-3
66. Verma V, Paul A, Vishwanath AA, et al., 2019, Understanding
55. Zuckerman L, Weiner I, 2005, Maternal immune activation intellectual disability and autism spectrum disorders from
leads to behavioral and pharmacological changes in the common mouse models: Synapses to behaviour. Open Biol,
adult offspring. J Psychiatr Res, 39: 311–323. 9: 180265.
https://doi.org/10.1016/j.jpsychires.2004.08.008 https://doi.org/10.1098/rsob.180265
56. Shi L, Fatemi SH, Sidwell RW, et al., 2003, Maternal influenza 67. Hyman BT, Yuan J, 2012, Apoptotic and non-apoptotic roles
infection causes marked behavioral and pharmacological of caspases in neuronal physiology and pathophysiology.
changes in the offspring. J Neurosci, 23: 297–302. Nat Rev Neurosci, 13: 395–406.
https://doi.org/10.1523/jneurosci.23-01-00297.2003 https://doi.org/10.1038/nrn3228
57. Chez MG, Guido-Estrada N, 2010, Immune therapy in 68. Suárez-Pereira I, García-Domínguez I, Bravo L, et al., 2022,
autism: Historical experience and future directions with The absence of caspase-8 in the dopaminergic system leads
immunomodulatory therapy. Neurotherapeutics, 7: 293–301. to mild autism-like behavior. Front Cell Dev Biol, 10: 839715.
https://doi.org/10.1016/j.nurt.2010.05.008 https://doi.org/10.3389/fcell.2022.1040623
58. Trifonova EA, Klimenko AI, Mustafin ZS, et al., 2021, 69. El-Ansary A, Al-Ayadhi L, 2012, Neuroinflammation in
Do autism spectrum and autoimmune disorders share autism spectrum disorders. J Neuroinflamm, 9: 265.
predisposition gene signature due to mTOR signaling
pathway controlling expression? Int J Mol Sci, 22: 5248. https://doi.org/10.1186/1742-2094-9-265
https://doi.org/10.3390/ijms22105248 70. El-Ansary AK, Ben Bacha AG, Al-Ayadhi LY, 2011,
Proinflammatory and proapoptotic markers in relation to
59. Wu S, Ding Y, Wu F, et al., 2015, Family history of mono and di-cations in plasma of autistic patients from
autoimmune diseases is associated with an increased risk of Saudi Arabia. J Neuroinflamm, 8: 142.
autism in children: A systematic review and meta-analysis.
Neurosci Biobehav Rev, 55: 322–332. https://doi.org/10.1186/1742-2094-8-142
https://doi.org/10.1016/j.neubiorev.2015.05.004 71. Paulsen M, Ussat S, Jakob M, et al., 2008, Interaction with
XIAP prevents full caspase-3/-7 activation in proliferating
60. Rudolph MD, Graham AM, Feczko E, et al., 2018, Maternal human T lymphocytes. Eur J Immunol, 38: 1979–1987.
IL-6 during pregnancy can be estimated from newborn
brain connectivity and predicts future working memory in https://doi.org/10.1002/eji.200838211
offspring. Nat Neurosci, 21: 765–772. 72. Bauernfeind F, Ablasser A, Bartok E, et al., 2011,
https://doi.org/10.1038/s41593-018-0128-y Inflammasomes: Current understanding and open
questions. Cell Mol Life Sci, 68: 765–783.
61. Rasmussen JM, Graham AM, Entringer S, et al., 2019,
Maternal Interleukin-6 concentration during pregnancy is https://doi.org/10.1007/s00018-010-0567-4
associated with variation in frontolimbic white matter and 73. Ruiz-Vela A, Opferman JT, Cheng EH, et al., 2005,
cognitive development in early life. Neuroimage, 185: 825–835. Proapoptotic BAX and BAK control multiple initiator
https://doi.org/10.1016/j.neuroimage.2018.04.020 caspases. EMBO Rep, 6: 379–385.
62. Hornig M, Bresnahan MA, Che X, et al., 2018, Prenatal fever https://doi.org/10.1038/sj.embor.7400375
and autism risk. Mol Psychiatry, 23: 759–766. 74. Siniscalco D, Sapone A, Giordano C, et al., 2012, The
https://doi.org/10.1038/mp.2017.119 expression of caspases is enhanced in peripheral blood
mononuclear cells of autism spectrum disorder patients.
63. Steinman L, Conlon P, Maki R, et al., 2003, The intricate
interplay among body weight, stress, and the immune J Autism Dev Disord, 42: 1403–1410.
response to friend or foe. J Clin Invest, 111: 183–185. https://doi.org/10.1007/s10803-011-1373-z

Volume 2 Issue 2 (2023) 20 https://doi.org/10.36922/an.391