Page 33 - ARNM-1-1

Advances in Radiotherapy &

Nuclear Medicine

ORIGINAL RESEARCH ARTICLE
Safety and effectiveness of selective internal

radiation therapy with SIR-Spheres Y-90 resin
microspheres for treatment of hepatocellular

carcinoma: A prospective observational study

Khoa Mai Trong , Bang Mai Hong , Thong Pham Minh , Luu Vu Dang ,
3
2†
1†
3
2
3
2
4
Binh Tran Hai , Chau Ha Trinh , Thinh Nguyen Tien , Ky Thai Doan ,
1
1
1
Thai Pham Van , Anh Nguyen Duy , and Phuong Pham Cam *
1 The Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam
2 Department of Gastroenterology, 108 Military Central Hospital, Hanoi, Vietnam
3 The Radiology Center, Bach Mai Hospital, Hanoi, Vietnam
4 Department of Oncology, Tam Anh Hospital, Hanoi, Vietnam
Abstract
The study aimed to evaluate the safety and effectiveness of selective internal
radiation therapy (SIRT) in patients with unresectable hepatocellular carcinoma
† These authors contributed equally (HCC) in Vietnam. A single-arm, multicenter, prospective observational study on
to the work. the use of SIRT in patients with HCC was conducted with 6 months of patient
*Corresponding author: follow-up. At baseline, eligible patients had Eastern Cooperative Oncology
Phuong Pham Cam Group (ECOG) status ≤1, total bilirubin ≤2 mg/dL, tumor burden ≤50%, Child-
(camphuongmd@yahoo.com) Pugh score A or ≤B7, and Barcelona Clinic Liver Cancer stage A – C. Patients with
Citation: Trong KM, Hong BM, extrahepatic disease, signs of liver failure, or previous external beam radiation
Minh TP, et al., 2023, Safety and to the liver were excluded. Primary outcomes were tumor response according to
effectiveness of selective internal
radiation therapy with SIR- modified Response Evaluation Criteria in Solid Tumors criteria, changes in liver
Spheres Y-90 resin microspheres function, and adverse events (AEs) assessed using Common Terminology for
for treatment of hepatocellular AEs v4.03 and the investigators’ clinical judgment. The secondary outcome was
carcinoma: A prospective
observational study. Adv Radiother the percentage of patients alive at 6 months. Two centers enrolled 30 patients
Nucl Med. (median age 60 years) in 2017 and 2018. All patients were Child-Pugh A; among
https://doi.org/10.36922/arnm.0385 them, 28 were ECOG 0. Most had hepatitis B (n = 17, 57%) or D (n = 10, 33%).
Received: April 1, 2023 Target lesion response at 6 months was 23% complete response, 37% partial
response, 7% stable disease, and 7% progressive disease. Of the 8 patients (27%)
Accepted: June 18, 2023
not evaluated, 2 had become eligible for resection, 2 had contraindications to
Published Online: July 5, 2023 imaging, and 4 were lost to follow-up. Laboratory values, including α-fetoprotein,
Copyright: © 2023 Author(s). did not change significantly from baseline to 6 months. The most common AEs
This is an Open Access article were abdominal pain (37%) and vomiting (17%). Nine episodes of abdominal pain
distributed under the terms of the
Creative Commons Attribution in 6 patients were treatment-related. Serious AEs included progressive cirrhosis
License, permitting distribution, and (n = 1) and progression of HCC (n = 5). All patients were alive at 6 months. In
reproduction in any medium, which conclusion, the safety and clinical effectiveness of SIRT were confirmed in patients
provided that the original work is
properly cited. with unresectable HCC in Vietnam.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Unresectable hepatocellular carcinoma; Selective internal radiation therapy;
regard to jurisdictional claims in Liver cancer; Vietnam
published maps and institutional
affiliations.

Volume 1 Issue 1 (2023) 1 https://doi.org/10.36922/arnm.0385