Page 61 - ARNM-1-2

Advances in Radiotherapy &

Nuclear Medicine

CASE REPORT
A case of primary pulmonary follicular dendritic

cell sarcoma

Min Yang , Hongcheng Zhong , Xinghua He , and Hongjun Jin *
2
3
1
1
1 Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated
Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China
2 Thoracic Surgery Department, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai,
Guangdong Province 519000, China
3 Nuclear Medicine Department, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai,
Guangdong Province 519000, China

Abstract
Here, we report a 66-year-old woman who presented with an irregular and lobulated
pulmonary mass in the apical segment of the right superior lobe with an enlarged
mediastinal lymph node. Abdominal computed tomography (CT), brain magnetic
resonance imaging, and fluorine-18 fluorodeoxyglucose positron emission

tomography/CT scans showed no extrapulmonary distant metastases. The patient
underwent surgical sleeve resection of the right superior lobe with systematic hilar
and mediastinal lymph node dissection. Post-operative histopathology, including
hematoxylin and eosin staining, immunohistochemistry, and Epstein–Barr virus
in situ hybridization, suggested primary pulmonary follicular dendritic cell sarcoma
(FDCS). A follow-up plain chest CT indicated recurrence with multiple metastases of
*Corresponding author: the liver, ribs, and mediastinal lymph nodes 1 year after surgery. The patient declined
Hongjun Jin further therapy and was lost follow-up. In this case, FDCS located in the lung was
(jinhj3@mail.sysu.edu.cn)
unusual and rare. Corresponding imaging and histopathological features have
Citation: Yang M, Zhong H, He X, enhanced our understanding of this disease. Meanwhile, it is necessary to include
2023, A case of primary pulmonary this tumor as a differential diagnosis of lung tumors and pay particular attention to
follicular dendritic cell sarcoma. Adv
Radiother Nucl Med, 1(2): 0824 the possibility of post-operative recurrence and metastasis. Moreover, considering
https://doi.org/10.36922/arnm.0824 the heterogeneity of FDCS, it is essential to identify the biological or imaging
Received: April 24, 2023 features that can reflect or predict the high risk of tumor recurrence and metastasis.
A corresponding post-operative examination is also necessary to determine if any
Accepted: June 29, 2023
lesions remain.
Published Online: July 13, 2023
Copyright: © 2023 Author(s). Keywords: Pulmonary follicular dendritic cell sarcoma; Lung cancer; Positron emission
This is an Open Access article
distributed under the terms of the tomography/computed tomography
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Background
Publisher’s Note: AccScience Follicular dendritic cell sarcoma (FDCS) is a rare low-grade malignant neoplasm that
Publishing remains neutral with originates from follicular dendritic cells, predominantly involving the lymph nodes . In
[1]
regard to jurisdictional claims in
published maps and institutional general, lung involvement typically represents metastatic disease. In this case, we report
affiliations. a rare primary pulmonary FDCS.

Volume 1 Issue 2 (2023) 1 https://doi.org/10.36922/arnm.0824