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Advances in Radiotherapy
& Nuclear Medicine Outcomes of durations in 2D and 3D BT for CCA

radiotherapy for patients with cervical cancer has been complications associated with prolonged treatment in this
investigated. Van Leeuwen et al. studied the effect of patient group emphasizes the need for strict adherence to
30
the interval between EBRT and hyperthermia on the treatment protocols.
rates of intracavitary recurrence, OS, and late toxicity in Conversely, 3D brachytherapy appears to provide a
women with advanced cervical cancer. They found that more favorable risk profile, allowing for extended treatment
administering hyperthermia shortly after EBRT can reduce durations without significantly increasing the risk of
the risk of intracavitary recurrence and improve OS, with adverse outcomes. This suggests that 3D brachytherapy
no significant differences in late toxicity. This suggests that is the preferred treatment approach for patients with
a combination of hyperthermia and radiotherapy may be advanced disease, as it enhances local pelvic control rates
a promising approach for the treatment of cervical cancer. while minimizing complications.
Further evaluation of such combined therapies could be
beneficial in optimizing treatment outcomes. Further studies are warranted to explore the optimal
treatment protocols for different brachytherapy techniques,
This study still has certain limitations: (1) The study emphasizing the importance of close monitoring of early
is based on retrospectively obtained data. Furthermore, and late rectal and bladder reactions in all patients.
although the clinical data were subjected to PSM, some
inherent bias in the matched data may still exist. (2) The Acknowledgments
data on adverse reactions and complications is not
comprehensive, which could be attributed to the quality of None.
data collection during the study. (3) Although the study Funding
had a relatively large sample size, the sample sizes and data
of the two groups differed after applying the PSM or IPTW This study was supported by the National Natural Science
method. This may have introduced variability. With the Foundation of China (Grant no.: 82373194).
gradual popularization of 3D brachytherapy, the difference
in patient data may be reduced. Therefore, future research Conflict of interest
should include more prospective studies to guide clinical Minglei Kang and Liming Xu are the Editorial Board
treatment, overcome these limitations, and provide more Members of this journal but were not in any way involved
robust and conclusive insights into the treatment of in the editorial and peer-review process conducted for
cervical cancer. this paper, directly or indirectly. Separately, other authors
This study’s results demonstrate that when using IMRT declared that they have no known competing financial
in combination with 3D brachytherapy for the treatment of interests or personal relationships that could have
cervical cancer, the treatment duration does not need to be influenced the work reported in this paper.
limited to 56 days. This flexibility can better accommodate Author contributions
the timing of surgeries, chemotherapy, and other adjuvant
treatments for patients. Thus, it could improve patient Conceptualization: Xiangpan Li, Liming Xu, Haonan
compliance and overall treatment outcomes. However, Han,Hailing Hou
weighing the benefits against the potential advantages Data curation: Hailing Hou, Lin Qiu, Tingting Chen,
of reducing the total treatment duration, such as time Yanling Yang
and cost savings, and increased utilization of imaging Formal analysis: Haonan Han, Hailing Hou
equipment is essential. A comprehensive assessment Investigation: Haonan Han, Hailing Hou
should consider both patient outcomes and resource Methodology: Haonan Han, Hailing Hou
utilization. It is hoped that future studies will continue to Validation: Hailing Hou, Lin Qiu, Tingting Chen, Yanling
focus on providing better treatment options for patients Yang
with cervical cancer. Writing – original draft: Haonan Han, Hailing Hou
Writing – review & editing: Chingyun Cheng, Keying Xu,
5. Conclusion Minglei Kang, Haonan Han, Hailing Hou

This study revealed significant differences in optimal Ethics approval and consent to participate
radiotherapy duration for patients with cervical cancer
based on various techniques. Our findings indicate that The study was approved by the Human Investigation
limiting treatment to 56 days can help mitigate the risks Committee of Tianjin Medical University Cancer Hospital,
of recurrence and metastasis in patients receiving 2D Tianjin, China. The patients gave consent to participate in
brachytherapy. However, the increased incidence of this study.

Volume 2 Issue 4 (2024) 10 doi: 10.36922/arnm.4310