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Advances in Radiotherapy
& Nuclear Medicine Aspirin’s protective effect on RISI

Funding of radiation-induced skin injury and implications for future
clinical trials. Int J Radiat Biol. 2013;89:311-318.
None.
doi: 10.3109/09553002.2013.765055
Conflict of interest 5. Jiang H, Swacha P, Aung KM, Gekara NO. Aspirin protects

The authors declare they have no competing interests. against genotoxicity by promoting genome repair. Cell Res.
2023;33(4):325-327.
Author contributions doi: 10.1038/s41422-023-00783-6

Conceptualization: Zhaoming Zhou, Wei Qiao 6. Laube M, Kniess T, Pietzsch J. Development of antioxidant
Data curation: All authors COX-2 inhibitors as radioprotective agents for radiation
Formal analysis: Yong Feng therapy-A hypothesis-driven review. Antioxidants (Basel).
Funding acquisition: Wei Qiao 2016;5(2):14.
Investigation: Zhaoming Zhou doi: 10.3390/antiox5020014
Methodology: Zhaoming Zhou 7. Li X, Heyer WD. Homologous recombination in DNA repair
Project administration: Yong Feng and DNA damage tolerance. Cell Res. 2008;18(1):99-113.
Resources: Wei Qiao
Software: Zhaoming Zhou doi: 10.1038/cr.2008.1
Supervision: Wei Qiao 8. Kim KY, Seol JY, Jeon GA, Nam MJ. The combined treatment
Validation: Zhaoming Zhou of aspirin and radiation induces apoptosis by the regulation
Visualization: Zhaoming Zhou of bcl-2 and caspase-3 in human cervical cancer cell. Cancer
Writing – original draft: Zhaoming Zhou Lett. 2003;189(2):157-166.
Writing – review & editing: All authors doi: 10.1016/S0304-3835(02)00519-0

Ethics approval and consent to participate 9. Curras-Alonso S, Soulier J, Defard T, et al. An interactive
murine single-cell atlas of the lung responses to radiation
This study did not include human participants, human data, injury. Nat Commun. 2023;14(1):2445.
or human tissue. The animal experiments were carried out doi: 10.1038/s41467-023-38134-z
in accordance with ethical procedures and the protocols
were approved by the Ethics Committee for Laboratory 10. Hoeller U, Tribius S, Kuhlmey A, Grader K, Fehlauer F,
Animals of the Southern Medical University (L2019074). Alberti W. Increasing the rate of late toxicity by changing the
score? A comparison of RTOG/EORTC and LENT/SOMA
Consent for publication scores. Int J Radiat Oncol Biol Phys. 2003;55(4):1013-1018.
Not applicable. doi: 10.1016/S0360-3016(02)04202-5
11. Gribov A, Sill M, Lück S, et al. SEURAT: Visual analytics
Availability of data for the integrated analysis of microarray data. BMC Med
The data used in this study will be available from the Genomics. 2010;3(1):21.
corresponding author upon reasonable request. doi: 10.1186/1755-8794-3-21

References 12. Yu G, Wang LG, Han Y, He QY. clusterProfiler: An R package
for comparing biological themes among gene clusters.
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Volume 3 Issue 1 (2025) 69 doi: 10.36922/arnm.5829