Page 79 - ARNM-3-1

Advances in Radiotherapy &

Nuclear Medicine

ORIGINAL RESEARCH ARTICLE
Dosimetric analysis of the cone beam-focused

gamma knife

3
1,2
Shan-Chuan Li , Shao-Run Gong , Xiao-Feng Zhang , Gang Li , Feng Zhang ,
2
3
2
2
Jun-Feng Wang *, Shuang Zhang , Chun-Li Zhang , and Jun Li 3
3
2
1 Xi’an Zhenhe Medical Technology Company Limited, Xi’an, Shaanxi, China
2 CNNC Cheng Imaging (Xi’an) Medical Equipment Company Limited, Xi’an, Shaanxi, China
3 CNNC High Energy Equipment (Tianjin) Company Limited, Tianjin, China
Abstract
This study presents the first report on the fundamental dosimetric characterization
of a novel image-guided radiosurgery system – the ZND-A Smart Knife (CNCI
Co., Ltd, Xi’an, China). The dosimetric performance of this radiosurgery system
was evaluated based on key parameters, including positioning reference point
deviation, nominal focal point dose rate, focusing field size, dose gradient, and
comprehensive error in dose calculation. The system employs “triple rotating
and focusing” technique, and its dosimetric characteristics were measured. The
*Corresponding author:
Jun-Feng Wang maximum positioning reference point deviation for collimator #1 – 4 was 0.38 mm;
(wangjunfeng@cnci-ms.com) the corresponding dose gradients were 3.1 mm, 3.4 mm, 5.4 mm, and 7.7 mm,
respectively. In dose calculation, the maximum isocenter point dose deviation
Citation: Li S, Gong S, Zhang
X, et al. Dosimetric analysis of was 3.3%, and the area overlap ratio for the largest collimator (#4) reached 98.3%.
the cone beam-focused gamma These results demonstrate excellent dosimetric performance and clinical potential,
knife. Adv Radiother Nucl Med. confirming the safety and precision of the next-generation cone beam-focused
2025;3(1):71-81.
doi: 10.36922/arnm.6280 gamma knife system.
Received: November 19, 2024
1st revised: November 28, 2024 Keywords: Cone beam-focused gamma knife; EBT3 film; Electrostatic meter; Radiation
dosimetry; Stereotactic radiation therapy
2nd revised: December 31, 2024
3rd revised: January 23, 2025
4th revised: February 5, 2025
1. Introduction
Accepted: February 5, 2025
With the rapid economic and social development in China, cancer incidence among
Published online: March 3, 2025 Chinese residents has been increasing year by year. Thus, cancer prevention and
Copyright: © 2025 Author(s). treatment have become an important public health issue in China. Stereotactic
1
This is an Open-Access article radiotherapy (SRT) is a method of treating tumors by irradiating the lesion, including
distributed under the terms of the
Creative Commons Attribution potential surrounding regions, with multiple beams and angles to maximize therapeutic
License, permitting distribution, efficacy. It effectively addresses the limitations of conventional treatments, which may
and reproduction in any medium,
2
provided the original work is fail to deliver a radical dose to critical areas of the lesion. Therefore, research and
properly cited. development, technological innovation, and measurement methodologies for SRT
Publisher’s Note: AccScience equipment have important implications for healthcare in China. This study conducts a
Publishing remains neutral with comprehensive dosimetric characterization of the next-generation Gamma Knife system
regard to jurisdictional claims in
published maps and institutional – the ZND-A Smart Knife – to validate its technical accuracy and operational safety for
affiliations. clinical deployment.

Volume 3 Issue 1 (2025) 71 doi: 10.36922/arnm.6280