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Advances in Radiotherapy
& Nuclear Medicine CS@LGG for acute radiation-induced bowel injury alleviation

Acknowledgments References

We would like to thank CHI BIOTECH Co., Ltd. for 1. Radiation bowel disease. Lancet. 1984;324:963-964.
their assistance with the whole transcriptome sequencing doi: 10.1016/s0140-6736(84)91173-5
and bioinformatics analyses. We would also like to
acknowledge the assistance with the XPS, FTIR, and SEM 2. Leighton C, Fisher B, Perera F. Acute radiation proctitis.
Lancet. 2001;357(9252):306.
analyses offered by the technicians of Scientific Compass
(www.shiyanjia.com). The pictures of the experimental doi: 10.1016/s0140-6736(05)71745-1
flow chart and mechanistic illustration were created with 3. Bujko K. Neoadjuvant chemoradiation for fixed cT3 or cT4
BioRender.com. rectal cancer: Results of a Polish II multicentre phase III
study. J Clin Oncol. 2016;34:489.
Funding
doi: 10.1200/jco.2016.34.4_suppl.489
This work was supported by the National Natural Science 4. Bahadoer RR, Dijkstra EA, van Etten B, et al. Short-
Foundation of China (grant numbers: 82473567, 82273564, course radiotherapy followed by chemotherapy before
and 81903125); the Key Science & Technology Brainstorm total mesorectal excision (TME) versus preoperative
Project of Guangzhou (grant number: 202206010045); the chemoradiotherapy, TME, and optional adjuvant
Guangdong Basic and Applied Basic Research Foundation chemotherapy in locally advanced rectal cancer (RAPIDO):
(grant numbers: 2023A1515030044, 2023A1515010502, A randomised, open-label, phase 3 trial. Lancet Oncol.
and 2024A1515013292); and the Science and Technology 2021;22:29-42.
Plan Project of Jiangxi Provincial Administration of doi: 10.1016/s1470-2045(20)30555-6
Traditional Chinese Medicine (grant number: 2023A0060).
5. Jin J, Tang Y, Hu C, et al. Multicenter, randomized, phase III
Conflict of interest trial of short-term radiotherapy plus chemotherapy versus
long-term chemoradiotherapy in locally advanced rectal
The authors declare that they have no competing interests. cancer (STELLAR). J Clin Oncol. 2022;40:1681-1692.

Author contributions doi: 10.1200/jco.21.01667
6. Li P, Wuthrick E, Rappaport JA, et al. GUCY2C signaling
Conceptualization: Xinyi Gu, Lu Yu opposes the acute radiation-induced GI syndrome. Cancer
Formal analysis: Xinyi Gu Res. 2017;77(18):5095-5106.
Investigation: Xinyi Gu, Xusheng Wang
Methodology: Shengqi Yin, Yilin Zheng, Zhihao Zheng, doi: 10.1158/0008-5472.can-17-0859
Yaowei Zhang, Keli Chen, Yuqing Zhang 7. Lu L, Li W, Chen L, et al. Radiation-induced intestinal
Writing – original draft: Xinyi Gu, Lu Yu damage: Latest molecular and clinical developments. Future
Writing – review & editing: Lu Yu, Yi Ding Oncol. 2019;15(35):4105-4118.
doi: 10.2217/fon-2019-0416
Ethics approval and consent to participate
8. Bhanja P, Norris A, Gupta-Saraf P, Hoover A, Saha S.
The Animal Experimentation Ethics Committee of Nanfang BCN057 induces intestinal stem cell repair and mitigates
Hospital, Southern Medical University (Guangzhou, radiation-induced intestinal injury. Stem Cell Res Ther.
China), approved (Application No. NFYY-2018-0521) 2018;9(1):26.
and oversaw all experimental procedures to ensure that doi: 10.1186/s13287-017-0763-3
they were conducted in accordance with the standardized
protocols. 9. Rieder F, Brenmoehl J, Leeb S, Schölmerich J, Rogler G.
Wound healing and fibrosis in intestinal disease. Gut.
Consent for publication 2007;56:130-139.
doi: 10.1136/gut.2006.090456
Not applicable.
10. Suman S, Kallakury BVS, Fornace AJ Jr., Datta K.
Availability of data Fractionated and acute proton radiation show differential
intestinal tumorigenesis and DNA damage and repair
Due to our laboratory’s policies and confidentiality pathway response in Apc(Min/+) mice. Int J Radiat Oncol
agreements, we are unable to provide raw data. However, Biol Phys. 2019;105(3):525-536.
the processes of experimental design, analysis, and results,
as well as data analysis and processing, are fully described doi: 10.1016/j.ijrobp.2019.06.2532
in this article. 11. Husebye E, Skar V, Høverstad T, Iversen T, Melby K.

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