Page 30 - BH-1-2

Brain & Heart

PERSPECTIVE ARTICLE
Autonomic nerve and its modulation

approaches for heart failure

1,2
Hanyu Zhang 1,2† , Yanfang Zhu 1,2† , Siyu Chen 1,2† , Keqiong Deng , Meng Zheng ,
1,2
1,2
Ziyue Zeng , Qiongxin Wang , Huanhuan Cai *, and Zhibing Lu *
1,2
1,2
1,2
1 Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
2 Institute of Myocardial Injury and Repair, Wuhan University, Wuhan, China
Abstract
Heart failure, a condition that arises from numerous cardiovascular disorders, is a primary
contributor to mortality related to cardiovascular disease. Typically noticed in heart
failure is heightened sympathetic activity coupled with diminished parasympathetic
activity. The autonomic nervous system governs the heart’s neurological regulation
through opposing functions of its sympathetic and parasympathetic components,
which regulate conduction velocity, heart rate, coronary blood flow, and contractile
force. Promising treatments for heart failure include inhibiting the sympathetic
nerve’s overactivity and restoring parasympathetic activity in the heart. In this review,
we describe neural modulation approaches that have potential to assist in the
management of heart failure.
† These authors contributed equally
to this work.
*Corresponding authors: Keywords: Sympathetic nerve; Parasympathetic nerve; Heart failure
Huanhuan Cai
(caihuanhuan@whu.edu.cn)
Zhibing Lu
(luzhibing222@163.com)
1. Introduction
Citation: Zhang H, Zhu Y, Chen S,
et al., 2023, Autonomic nerve and Despite significant advancements in treatment, heart failure (HF) continues to pose a
its modulation approaches for heart major global public health concern, affecting approximately 64.3 million individuals
failure. Brain & Heart, 1(2): 0913.
[1]
https://doi.org/10.36922/bh.0913 worldwide and resulting in substantial mortality rates . Active intervention in heart
failure, which would improve patients’ prognoses by lowering hospitalization and
Received: May 6, 2023
mortality rates, has been a major topic and a key challenge in the clinical management
Accepted: June 28, 2023 of heart failure . With the advancement of heart failure research and a better
[2]
Published Online: July 19, 2023 understanding of the disease, regulating heart remodeling has become an important
topic in heart failure treatment [3,4] . It has been established that electrical remodeling,
Copyright: © 2023 Author(s).
This is an Open Access article which plays a crucial role in the onset and progression of heart failure, is a common
distributed under the terms of the pathway for many cardiovascular diseases to progress to heart failure and affects
Creative Commons Attribution patients’ prognoses [2,3] . The autonomic nervous system modulates cardiac function by
License, permitting distribution,
and reproduction in any medium, balancing sympathetic and parasympathetic inputs to the heart. In the face of external
provided the original work is stimuli, multiple feedback loops regulate the autonomic balance and enable the heart
properly cited. to adapt to changing circumstances. An elevated sympathetic nerve activity, which
Publisher’s Note: AccScience is a manifestation of autonomic nervous system dysfunction, plays a pivotal role in
Publishing remains neutral with instigating and advancing heart remodeling, ultimately leading to heart failure [5-7] .
regard to jurisdictional claims in
published maps and institutional This review describes various neuromodulation approaches currently available for the
affiliations. management of heart failure.

Volume 1 Issue 2 (2023) 1 https://doi.org/10.36922/bh.0913