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Brain & Heart

CASE REPORT
Operative treatment for umbilical venous

catheter-related Staphylococcus aureus
infective endocarditis with subsequent septic

thrombosis: A case report

3
1
2
Cassandra DeVol , Christopher M. McDaniel , Nupur Singh , and
Pilar Anton Martin *
4
1 Division of Pediatric Cardiology, University of Tennessee Health Science Center/Le Bonheur
Children’s Hospital, Memphis, TN, USA
2 Division of Internal Medicine, Baptist Memorial Hospital-DeSoto, Memphis, TN, USA
3 Department of Medical Education, College of Medicine, University of Tennessee Health Science
Center, Memphis, TN, USA
4 Division of Anesthesia and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia,
PA, USA

Abstract
Thrombosis and infective endocarditis are significant causes of morbidity and
mortality in critically ill children, especially with the increasing use of indwelling
catheters. In some cases, surgical excision becomes imperative to ensure adequate
source control and mitigate the burden of infection. Herein, we present a compelling
*Corresponding author: case involving a term neonate who developed refractory Staphylococcus aureus
Pilar Anton Martin infective endocarditis, followed by septic emboli due to a thrombus associated
(pilarantonmartin@gmail.com) with a malpositioned indwelling umbilical venous catheter (UVC). Thrombosis and
Citation: DeVol C, McDaniel CM, infective endocarditis resolved after surgical resection, a 6-week course of antibiotics,
Singh N, et al., 2023, Operative and anticoagulation therapy for 3 months. This case report highlights the risk of
treatment for umbilical venous
catheter-related Staphylococcus thrombosis arising from malpositioned UVCs, the potential complications, and the
aureus infective endocarditis with treatment options.
subsequent septic thrombosis: A case
report. Brain & Heart, 1(2): 1005.
https://doi.org/10.36922/bh.1005 Keywords: Umbilical venous catheter; Infective endocarditis; Septic embolism; Newborn;
Received: May 26, 2023 Neonate
Accepted: July 25, 2023
Published Online: August 23, 2023
Copyright: © 2023 Author(s). 1. Background
This is an Open Access article
distributed under the terms of the Indwelling catheters remain a risk factor for thrombosis and infections in hospitalized
Creative Commons Attribution infants [1,2] . Several reports underscore the association between neonatal thrombosis and
License, permitting distribution, infective endocarditis (IE), particularly in cases related to umbilical venous catheters
and reproduction in any medium,
provided the original work is (UVCs) [1,2] . The occurrence of UVC-related infections and thromboses stems from
properly cited. a complex interplay of contributing factors. On catheter insertion, the endothelium
Publisher’s Note: AccScience sustains damage, resulting in the accumulation of fibrin and endothelial cells. This
Publishing remains neutral with initial damage, coupled with reduced blood flow and subsequent endothelial erosions,
regard to jurisdictional claims in
published maps and institutional further contributes to thrombus formation. These thrombi can serve as a nidus for
affiliations. bacterial superinfection. Furthermore, the inflammation triggered by the primary

Volume 1 Issue 2 (2023) 1 https://doi.org/10.36922/bh.1005