Page 49 - BH-1-2

Brain & Heart RDN guided by novel blood pressure responses

Table 2. Characteristic parameters of five BP response patterns
No. SBP change , mmHg Occurrence time , (s)
a
b
Minimum Maximum End‑stimulation Minimum Maximum End‑stimulation
Type 1 74 3.7±5.0 14.3±8.9 11.6±7.9 16.9±7.7 21.2±11.2 27.0±14.5
Type 2 47 −14.0±7.1 13.2±7.6 8.3±9.6 14.2±3.5 23.4±9.5 32.3±9.1
Type 3 50 −16.7±8.4 −1.8±5.9 −3.6±5.6 17.9±6.3 31.1±13.1 40.7±12.7
Type 4 71 −1.0±2.1 1.3±2.0 0.3±2.2 17.5±6.7 18.3±11.9 24.6±11.3
Type 5 18 −12.5±7.4 −5.3±5.7 −11.4±7.3 24.9±11.2 16.0±12.9 30.4±14.2
Notes: Values are mean±SD. Change of mean SBP compared to the first 10 cardiac cycles prior to electrical stimulation. Occurrence time interval
a
b
compared to the initiation of the electrical stimulation.
Abbreviation: SBP: Systolic blood pressure.
Table 3. Antihypertensive drugs at baseline and follow‑ups A

Baseline 5 – 7 days 6 – 12
months
No. of antihypertensive medications 2.9±1.3 3.0±1.3 2.4±1.2
ACE-I/ARB 10 10 7
Calcium channel blockers 11 10 9
Beta adrenoceptor-blocking agents 10 10 11
Diuretic 7 9 6
Alpha adrenoceptor-blocking agents 2 2 0
Notes: Values are mean±SD or n.
Abbreviations: ACE-I: Angiotensin-converting enzyme inhibitor;
ARB: Angiotensin receptor blockers.

B

Figure 4. Changes in ambulatory blood pressure and heart rate after
selective RDN. (A) Consistent decrease of ambulatory blood pressure
(BP) and heart rate at 5 – 7 days and 6 – 12 months after renal denervation
(RDN). (B) Mean and standard error of postoperative ambulatory BP
Figure 3. Electrical stimulation-induced changes in SBP before and drop. *P < 0.05 and. P < 0.001 for comparison between baseline and 5 –
#
after RDN. After renal denervation (RDN), systolic blood pressure 7 days and 6 – 12 months by univariate repeated measurement analysis
(SBP) elevations during repeated renal stimulation (RNS) were blunted of variance.
significantly in sites with type 1 and type 2. *P < 0.05 and #P<0.001 for
comparison between before and after RDN by paired sample t-test.
evaluated the changes in BP after selective RDN in
4. Discussion patients with hypertension. We mainly obtained the
following results: (i) RNS can evoke five types of rapid BP
This study summarized several types of rapid BP responses. Biphasic changes (drop before rise) of SBP can
response patterns caused by electrical stimulation and be elicited successively at some sites. (ii) ABP and heart

Volume 1 Issue 2 (2023) 7 https://doi.org/10.36922/bh.0384