Page 72 - BH-2-1
P. 72
Brain & Heart Mesenchymal cell therapy for heart disease
22. Zhu W, Huang L, Li Y, et al. Exosomes derived from human 32. Zhang C, Zhou G, Chen Y, et al. Human umbilical cord
bone marrow mesenchymal stem cells promote tumor mesenchymal stem cells alleviate interstitial fibrosis and
growth in vivo. Cancer Lett. 2012;315(1):28-37. cardiac dysfunction in a dilated cardiomyopathy rat
model by inhibiting TNF-α and TGF-β1/ERK1/2 signaling
doi: 10.1016/j.canlet.2011.10.002
pathways. Mol Med Rep. 2018;17(1):71-78.
23. Tomasoni S, Longaretti L, Rota C, et al. Transfer of
growth factor receptor mRNA via exosomes unravels the doi: 10.3892/mmr.2017.7882
regenerative effect of mesenchymal stem cells. Stem Cells 33. Ciszek B, Skubiszewska D, Ratajska A. The anatomy of the
Dev. 2013;22(5):772-780. cardiac veins in mice. J Anat. 2007;211(1):53-63.
doi: 10.1089/scd.2012.0266 doi: 10.1111/j.1469-7580.2007.00753.x
24. Yu B, Gong M, Wang Y, et al. Cardiomyocyte protection by 34. Price MJ, Chou CC, Frantzen M, et al. Intravenous
GATA-4 gene engineered mesenchymal stem cells is partially mesenchymal stem cell therapy early after reperfused acute
mediated by translocation of miR-221 in microvesicles. myocardial infarction improves left ventricular function
PLoS One. 2013;8(8):e73304. and alters electrophysiologic properties. Int J Cardiol.
2006;111(2):231-239.
doi: 10.1371/journal.pone.0073304
doi: 10.1016/j.ijcard.2005.07.036
25. Huang P, Wang L, Li Q, et al. Combinatorial treatment of
acute myocardial infarction using stem cells and their 35. Qi CM, Ma GS, Liu NF, et al. Transplantation of magnetically
derived exosomes resulted in improved heart performance. labeled mesenchymal stem cells improves cardiac function
Stem Cell Res Ther. 2019;10(1):300. in a swine myocardial infarction model. Chin Med J (Engl).
2008;121(6):544-550.
doi: 10.1186/s13287-019-1353-3
doi: 10.1097/00029330-200803020-00016
26. Zlatanova I, Pinto C, Silvestre JS. Immune modulation of
rd
cardiac repair and regeneration: The art of mending broken 36. Hamamoto H, Gorman JH 3 , Ryan LP, et al. Allogeneic
hearts. Front Cardiovasc Med. 2016;3:40. mesenchymal precursor cell therapy to limit remodeling
after myocardial infarction: The effect of cell dosage. Ann
doi: 10.3389/fcvm.2016.00040 Thorac Surg. 2009;87(3):794-801.
27. Van Den Akker F, De Jager SCA, Sluijter JPG. doi: 10.1016/j.athoracsur.2008.11.057
Mesenchymal stem cell therapy for cardiac inflammation:
Immunomodulatory properties and the influence of toll-like 37. Karantalis V, Difede DL, Gerstenblith G, et al. Autologous
receptors. Mediators Inflamm. 2013;2013:181020. mesenchymal stem cells produce concordant improvements
in regional function, tissue perfusion, and fibrotic burden
doi: 10.1155/2013/181020 when administered to patients undergoing coronary
28. Lee RH, Pulin AA, Seo MJ, et al. Intravenous hMSCs improve artery bypass grafting: The prospective randomized study
myocardial infarction in mice because cells embolized in of mesenchymal stem cell therapy in patients undergoing
lung are activated to secrete the anti-inflammatory protein cardiac surgery (PROMETHEUS) trial. Circ Res.
TSG-6. Cell Stem Cell. 2009;5(1):54-63. 2014;114(8):1302-1310.
doi: 10.1016/j.stem.2009.05.003 doi: 10.1161/CIRCRESAHA.114.303180
29. Lemcke H, Voronina N, Steinhoff G, David R. Recent 38. Florea V, Rieger AC, DiFede DL, et al. Dose comparison
progress in stem cell modification for cardiac regeneration. study of allogeneic mesenchymal stem cells in patients with
Stem Cells Int. 2018;2018:1909346. ischemic cardiomyopathy (The TRIDENT study). Circ Res.
2017;121(11):1279-1290.
doi: 10.1155/2018/1909346
doi: 10.1161/CIRCRESAHA.117.311827
30. Orlic D, Kajstura J, Chimenti S, Dm B, Leri A, Anversa P.
Bone marrow stem cells regenerate infarcted myocardium. 39. Breitbach M, Bostani T, Roell W, et al. Potential risks of bone
Pediatr Transplant. 2003;7:86-88. marrow cell transplantation into infarcted hearts. Blood.
2007;110(4):1362-1369.
doi: 10.1034/j.1399-3046.7.s3.13.x
doi: 10.1182/blood-2006-12-063412
31. Mu Y, Cao G, Zeng Q, Li Y. Transplantation of induced
bone marrow mesenchymal stem cells improves the 40. Lin CS, Xin ZC, Dai J, Lue TF. Commonly used mesenchymal
cardiac function of rabbits with dilated cardiomyopathy stem cell markers and tracking labels: Limitations and
via upregulation of vascular endothelial growth factor and challenges. Histol Histopathol. 2013;28(9):1109-1116.
its receptors. Exp Biol Med (Maywood). 2011;236(9):1100- doi: 10.14670/HH-28.1109
1107.
41. Kandala J, Upadhyay GA, Pokushalov E, Wu S, Drachman DE,
doi: 10.1258/ebm.2011.011066 Singh JP. Meta-analysis of stem cell therapy in chronic
Volume 2 Issue 1 (2024) 6 https://doi.org/10.36922/bh.2065

