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Brain & Heart Alzheimer’s disease: Gene and protein network analysis

Figure 3. Construction of protein–protein interaction networks showing the top four significant gene modules

network corresponded to the strength or confidence of
the interaction data. The extensive web of connections
visualized the complexity of the post-transcriptional
regulation of these ribosomal components by miRNAs. In
terms of connectivity, the network comprised 248 edges,
highlighting the relationships between miRNAs and their
target genes. Some of the hub genes were targeted by a high
number of miRNAs; for instance, RPL15 was targeted by 81
miRNAs, RPL12 by 60 miRNAs, and RPL18 by 43 miRNAs.
In addition, RPL27 and RPL19 were targeted by a relatively
lower number of miRNAs (32 and 31, respectively).
These results illustrated the complex interplay between
miRNAs and hub genes in the regulatory network and
underscored the potential for miRNAs to highly regulate
Figure 4. Top 10 hub genes these proteins, suggesting that sophisticated gene
expression control is relevant to both normal cellular
representing a specific miRNA, such as hsa-miR-103-3p function and disease states. The identification of these
and hsa-miR-484-3p. The thickness of the edges in this hub genes and their associated miRNAs provided valuable

Volume 2 Issue 4 (2024) 6 doi: 10.36922/bh.2906