Page 176 - EJMO-9-1

Eurasian Journal of Medicine
and Oncology

ORIGINAL RESEARCH ARTICLE
Research on hypoxia and the extracellular matrix

in cancer: A visualization analysis

Xin Jiang 1] , Lilan Ou 1,2 , Xue Fan 1 , Jiaxin Yang 1 , Chun Zhang * ,
1,2
and Qiuyu Liu *
1
1 School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China
2 Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan,
China

Abstract

Hypoxia and the extracellular matrix (ECM) are critical drivers of metastasis. To
comprehensively analyze the development of hypoxia and ECM in cancer and identify
potential collaborative relationships, this study employs bibliometric methods to
analyze and predict emerging hotspots and potential research directions. This study
collected relevant research literature (published in English; 2007 – 2024) from the Web
of Science Core Collection using bibliometrics. The research status, hotspots, frontiers,
and trends in the field of “hypoxia and ECM and cancer” were analyzed using the R
package (bibliometrix). CiteSpace and VOSviewer were employed for visualizing the
*Corresponding authors: analysis of authors, countries, institutions, keywords, and co-cited references. A total of
Chun Zhang 2199 authors from 39 countries contributed to 351 articles published in 201 journals in
(zhangchun@swmu.edu.cn)
Qiuyu Liu the research domain. From 2007 to 2024, there was an overall increasing trend, with an
(q.liu@swmu.edu.cn) average annual growth rate of 13.54%. Developed countries, especially the United States
Citation: Jiang X, Ou L, Fan X, of America (USA) made major contributions, while China, despite its high publication
Yang J, Zhang C, Liu Q. Research volume, lagged in quality compared to the USA. Notably, Johns Hopkins University
on hypoxia and the extracellular demonstrated strong international collaboration. Cancer-associated fibroblast (CAF),
matrix in cancer: A visualization
analysis. Eurasian J Med Oncol. tumor microenvironment, and cancer metabolism are current major research areas,
2025;9(1):168-192. with future directions in clinical therapy. The analysis of hypoxia and ECM in cancer
doi: 10.36922/ejmo.7116 using bibliometrics reveals a rapid development from 2007 to 2016. International
Received: December 9, 2024 collaboration has intensified through partnerships with developed countries,
resulting in more in-depth research contributions from some developing countries.
Revised: December 26, 2024
These research efforts mainly focus on pancreatic cancer, lung cancer, glioblastoma
Accepted: January 6, 2025 multiforme, and breast cancer. CAF and glucose metabolic reprogramming associated
Published online: January 31, with hypoxia and ECM in cancer have garnered widespread attention. Research in these
2025 areas, particularly the challenges of clinical therapy resistance in triple-negative breast
Copyright: © 2025 Author(s). cancer closely associated with ECM, is expected to be key focal points in the future.
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Hypoxia; Extracellular matrix; Cancer; Bibliometric analysis; CiteSpace;
License, permitting distribution, VOSviewer
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional Hypoxia is the feature of solid malignant tumors caused by abnormal vascular structure
affiliations and microcirculation disorders, resulting in decreased oxygen percentage and adversely

Volume 9 Issue 1 (2025) 168 doi: 10.36922/ejmo.7116