Page 178 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
Research on hypoxia and ECM in cancer

Figure 1. Annual scientific publications (blue bars) and cumulative publications (orange line). In general, there is a noticeable upward trajectory in the
annual publication volume represented by the well-fitted red dashed line (R² = 0.754391; p < 0.0001).

3. Results Table 1. Top 10 countries by publications and citations
3.1. Growth and trend of publications Rank Country Articles TGCS SCP MCP
Figure 1 illustrates the trend of the annual publication N % n %
volume in the field of hypoxia and ECM in cancer from 1 China 112 31.9 3561 102 10 8.9
2007 to 2024. In general, there is a noticeable upward 2 USA 83 23.6 7688 59 24 28.9
trajectory in the annual publication volume represented by 3 Italy 18 5.1 1621 13 5 27.8
the well-fitted red dashed line (R = 0.754391; p < 0.0001). 4 United Kingdom 15 4.3 1676 9 6 40
2
The peak publication volume was observed in 2022, 5 India 12 3.4 701 9 3 25
with 52 reported publications. The growth displayed a 6 Korea 10 2.8 284 7 3 30
relatively stable pattern from 2007 to 2011, exhibited slight
fluctuations from 2011 to 2019 with a decline in 2012, and 7 Germany 9 2.6 680 7 2 22.2
an upward trend in subsequent years. The period from 8 Japan 9 2.6 185 9 0 0
2019 to 2022 marked a phase of rapid growth at a rate of 9 Australia 8 2.3 464 4 4 50
136.4%. However, the relevant research literature in this 10 Iran 7 2 629 5 2 28.6
area has been on a downward trend in the last 2 years (2023 Abbreviations: MCP: Multiple country publications; SCP: Single
and 2024). The average annual growth rate in the annual country publications; TGCS: Total global citations; USA: United States
publication volume of relevant literature from 2007 to 2024 of America.
is 13.54%, indicating an increasing involvement of scholars
in the research areas of hypoxia and ECM in cancer. the total articles. The USA also claims the highest citation
frequency at 7688, followed by China at 3561. All other
3.2. Country and region analysis countries/regions maintain citation frequencies below 2000.
There are 39 countries/regions actively engaging in the field Figures 2A and S1 visually elucidate the publication volume
of hypoxia and ECM in cancer. Table 1 delineates the top 10 and collaboration dynamics among different countries/
countries/regions based on publication volume, along with regions. Importantly, research on hypoxia and ECM in
corresponding citation frequencies and centrality metrics. cancer predominantly centers in the Northern Hemisphere,
The betweenness centrality of countries/regions serves as establishing robust connections among North America,
a gauge of their significance within the research network. Europe, and East Asia, particularly showcasing strong
Notably, China has the highest publication volume with 112 collaborative ties between North America and Europe.
papers, closely followed by the United States of America Figure 2 reveals the publication volume and international
(USA) with 83 papers, both of which account for 55.5% of collaboration status for each country of the corresponding

Volume 9 Issue 1 (2025) 170 doi: 10.36922/ejmo.7116