Page 182 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
Research on hypoxia and ECM in cancer

Krishnamachary B. and Mironchik Y. have maintained a publication volume. The color of the nodes represents the
strong collaborative relationship, co-authoring four papers average publication time of articles in each journal, and the
in 2015, 2017, 2018, and 2024, gradually deepening their connections between nodes indicate citation relationships
research in this field. among the journals.
Figure 4C presents a three-field plot analysis of author- Table 4 lists the top 10 most influential journals in
country-institution relationships. The left side represents this field, comprising a total of 71 papers, which accounts
authors, the middle indicates countries, and the right side for 20.23% of all publications. The top three prolific
indicates institutions. China has the strongest associations journals are Cancers (12 papers), International Journal
with both authors (8/10) and institutions (9/10), followed of Molecular Sciences (11 papers), and Frontiers in
by the USA (authors = 7/10; institutions = 7/10). Bhujwalla Oncology (nine papers). Among the top 10 journals, in
Z.M., the most prolific author, is linked to the USA, Spain, terms of publication volume, the top three cited journals
and Germany. are the International Journal of Molecular Sciences (945
citations), PLOS One (633 citations), and Clinical and
3.5. Journal and research category analysis Experimental Metastasis (540 citations). According to the
A total of 351 papers were published across 201 different h-index, Cancers has the highest h-index of 8, followed by
journals. In Figure 5A, a visualization analysis was Biomaterials (h-index = 7) and International Journal of
conducted based on 52 journals with over two publications. Molecular Sciences (h-index = 6).
The size of the nodes corresponds to the publication Figure 5B presents a double map overlay of scientific
volume of each journal, with larger nodes indicating higher journals. The left side displays the distribution of citing
literature in journals, representing the main disciplines
Table 2. Top 10 institutions by publications and citations of science mapping. The right side demonstrates the
distribution of cited literature, representing the disciplines
Rank Institution Publications Citations mainly referenced by science mapping. It is observed that
1 Johns Hopkins University 16 2040 articles in molecular, biology, and immunology mainly
2 Soochow University 9 726 cited literature from molecular, biology, and genetics.
3 Fudan University 8 250
4 Harvard University 8 933 3.6. Keyword analysis
5 Sun Yat-Sen University 8 117 VOSviewer was used to illustrate the visual analysis of
6 Chinese Academy of Sciences 7 568 keywords (Figure 6A). The node size denotes the frequency
7 Huazhong University of Science 7 223 of each keyword, while the node color represents the
and Technology average time of occurrence for the respective keywords.
8 University of California San Diego 7 739 Density accumulation is established based on the
interconnectedness of various keywords (Figure S4);
9 Zhejiang University 7 310 “hypoxia,” “extracellular matrix,” and “microenvironment”
10 University of Hong Kong 6 178 emerge as the three most prominent keywords. The

Table 3. Top 10 authors by h‑index
Rank Author H‑index G‑index M‑index TGCS Documents PY‑start
1 Bhujwalla Z.M. 8 9 0.444 259 9 2007
2 Wang Y. 5 6 0.333 702 6 2010
3 Yang J. 5 5 0.5 363 5 2015
4 Gilkes D.M. 4 4 0.333 1682 4 2013
5 Glunde K. 4 4 0.222 164 4 2007
6 Kakkad S. 4 4 0.286 89 4 2011
7 Mortezaee K. 4 4 0.667 597 4 2019
8 Semenza G.L. 4 4 0.333 1682 4 2013
9 Wang J. 4 5 0.267 667 5 2010
10 Wirtz D. 4 6 0.333 1686 6 2013
Abbreviation: TGCS: Total global citations.

Volume 9 Issue 1 (2025) 174 doi: 10.36922/ejmo.7116