Page 240 - EJMO-9-2
P. 240
Eurasian Journal of
Medicine and Oncology Quercetin effects in rats with liver injury
Gastroenterology. ACG clinical guideline: Diagnosis and doi: 10.3748/wjg.v20.i40.14787
management of idiosyncratic drug-induced liver injury. Am 12. Ullah A, Munir S, Badshah SL, et al. Important flavonoids
J Gastroenterol. 2021;116(5):878-898.
and their role as a therapeutic agent. Molecules.
doi: 10.14309/ajg.0000000000001121 2020;25(22):5243.
2. Singh D, Cho WC, Upadhyay G. Drug-induced liver toxicity doi: 10.3390/molecules25225243
and prevention by herbal antioxidants: An overview. Front 13. Da Silva Pereira Saccol R, Da Silveira KL, Manzoni AG,
Physiol. 2016;6:363.
et al. Antioxidant, hepatoprotective, genoprotective, and
doi: 10.3389/fphys.2015.00363 cytoprotective effects of quercetin in a murine model of
arthritis. Drug Chem Toxicol. 2020;43(5):504-511.
3. Zakaria ZA, Kamisan FH, Kek TL, Salleh MZ.
Hepatoprotective and antioxidant activities of Dicranopteris doi: 10.1080/01480545.2019.1619095
linearis leaf extract against paracetamol-induced liver 14. Hawas UW, El-Ansari MA, Osman AF, Galal AF, Abou
intoxication in rats. Pharm Biol. 2020;58(1):478-489.
El-Kassem LT. Flavonoid constituents and protective
doi: 10.1080/13880209.2020.1764058 efficacy of Citrus reticulate (Blanco) leaves ethanolic extract
on thioacetamide-induced liver injury rats. Biomarkers.
4. Wang X, Wu Q, Liu A, et al. Paracetamol: Overdose-induced
oxidative stress toxicity, metabolism, and protective effects 2023;28(2):160-167.
of various compounds in vivo and in vitro. Drug Metab Rev. doi: 10.1080/1354750X.2022.2151645
2017;49(4):395-437.
15. Pingili RB, Vemulapalli S, Narra UB, Potluri SV, Kilaru NB.
doi: 10.1080/03602532.2017.1354014 Diosmin attenuates paracetamol-induced hepato- and
5. Ahmed HM, Shehata HH, Mohamed GS, Abo-Gabal HH, nephrotoxicity via inhibition of CYP2E1-mediated
El-Daly SM. Paracetamol overdose induces acute liver metabolism in rats. J Appl Pharm Sci. 2023;13(12):96-104.
injury accompanied by oxidative stress and inflammation. doi: 10.7324/JAPS.2023.131212
Egypt J Chem. 2023;66(3):399-408.
16. Irwin MR, Curay CM, Choi S, Kiyatkin EA. Basic
doi: 10.21608/ejchem.2022.134110.5474 physiological effects of ketamine-xylazine mixture as a
6. Caparrotta TM, Antoine DJ, Dear JW. Are some people general anesthetic preparation for rodent surgeries. Brain
at increased risk of paracetamol-induced liver injury? Res. 2023;1804:148251.
A critical review of the literature. Eur J Clin Pharmacol. doi: 10.1016/j.brainres.2023.148251
2018;74(2):147-160.
17. Ayoub SS. Paracetamol (acetaminophen): A familiar drug
doi: 10.1007/s00228-017-2356-6 with an unexplained mechanism of action. Temperature
(Austin). 2021;8(4):351-371.
7. Rotundo L, Pyrsopoulos N. Liver injury induced by
paracetamol and challenges associated with intentional and doi: 10.1080/23328940.2021.1886392
unintentional use. World J Hepatol. 2020;12(4):125-136.
18. Offor SJ, Amadi CN, Chijioke-Nwauche I, Manautou JE,
doi: 10.4254/wjh.v12.i4.125 Orisakwe OE. Potential deleterious effects of paracetamol
8. Li J, Chiew AL, Isbister GK, Duffull SB. Sulfate conjugation dose regime used in Nigeria versus that of the United States
may be the key to hepatotoxicity in paracetamol overdose. of America. Toxicol Rep. 2022;9:1035-1044.
Br J Clin Pharmacol. 2021;87(5):2392-2396. doi: 10.1016/j.toxrep.2022.04.025
doi: 10.1111/bcp.14642 19. David AVA, Arulmoli R, Parasuraman S. Overviews of
9. Fujino C, Sanoh S, Katsura T. Variation in expression of biological importance of quercetin: A bioactive flavonoid.
cytochrome P450 3A isoforms and toxicological effects: Pharmacogn Rev. 2016;10(20):84-89.
Endo- and exogenous substances as regulatory factors and doi: 10.4103/0973-7847.194044
substrates. Biol Pharm Bull. 2021;44(11):1617-1634.
20. Dajas F. Life or death: Neuroprotective and anticancer effects
doi: 10.1248/bpb.b21-00332 of quercetin. J Ethnopharmacol. 2012;143(2):383-396.
10. Lewis PS. The Relevance of MicroRNAs and Circadian doi: 10.1016/j.jep.2012.07.005
Rhythms in Drug Safety. University of Liverpool. [Doctoral
Dissertation]; 2012. 21. Singh P, Arif Y, Bajguz A, Hayat S. The role of quercetin in
plants. Plant Physiol Biochem. 2021;166:10-19.
11. Madrigal-Santillán E, Madrigal-Bujaidar E, Álvarez-
González I, et al. Review of natural products with doi: 10.1016/j.plaphy.2021.05.023
hepatoprotective effects. World J Gastroenterol. 22. Elumalai P, Lakshmi S. Role of quercetin benefits in
2014;20(40):14787-14804. neurodegeneration. Adv Neurobiol. 2016;12:229-245.
Volume 9 Issue 2 (2025) 232 doi: 10.36922/ejmo.7873

