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Eurasian Journal of
            Medicine and Oncology                                           Novel senescence-based melanoma risk model




            A                             B


















            C                             D






















            E                              F
























            Figure 4. Validation of the risk model in the validation set and another external datasets. (A) Survival analysis of the high-risk and low-risk groups
            classified by the median risk score in the internal validation set. (B) Infiltration levels of immune cells in the two groups within the internal validation
            set. (C and E) Survival analysis of the two risk groups classified by the median risk score in the external GEO datasets: (C) GSE65904 and (E) GSE19234.
            (D and F) Infiltration levels of immune cells in the two groups within the external GEO datasets. The differences in infiltration levels between the two
            groups were calculated using the Wilcoxon rank-sum test. Notes: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.
            Abbreviations: NK: Natural killer; ns: Not significant.



            Volume 9 Issue 3 (2025)                         95                              doi: 10.36922/ejmo.8574
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