Page 30 - GPD-1-2

Gene & Protein in Disease

REVIEW ARTICLE
Insights into the role of RUNX1 gene in

female-related cancers

Sagarika Shahriar , Zarin Tasnim Rafa , Maiesha Samiha Mahmood ,
1†
1†
1†
2†
Deera Mahasin , Yusha Araf , Md. Asad Ullah , MD. Hasanur Rahman ,
1†
4
3
Md. Akkas Ali , Fatama Tous Zohora , Chunfu Zheng *, and
5
6
7,8
Mohammad Jakir Hosen *
5
1 Biotechnology Program, Department of Mathematics and Natural Sciences, School of Data and
Sciences, Brac University, Dhaka, Bangladesh
2 Department of Biotechnology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
3 Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences,
Jahangirnagar University, Savar, Dhaka, Bangladesh
4 Department of Biotechnology and Genetic Engineering, Faculty of Life Sciences, Bangabandhu
Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
5 Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal
University of Science and Technology, Sylhet, Bangladesh
6 Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani
Science and Technology University, Tangail 1902, Bangladesh
7 Department of Immunology, School of Basic Medical Sciences, Fujian Medical University,
Fuzhou, China
8 Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary,
Alberta, Canada
† These authors contributed equally
to this work.
*Corresponding authors: Abstract
Chunfu Zheng
(zheng.alan@gmail.com) The transcription factors of runt-related transcription factor (RUNX) are important
Mohammad Jakir Hosen
(jakir-gen@sust.edu) regulators of various developmental pathways, with roles in proliferation,
differentiation, apoptosis, and cell lineage. One of the core subclasses of the RUNX
Citation: Shahriar S, Rafa ZT,
Mahmood MS, et al., 2022, Insights family that codes for a number of transcription-binding proteins is the RUNX1 gene,
into the role of RUNX1 gene in which is located on chromosome 21q22.12. There has been extensive research on
female-related cancers. Gene RUNX1 mutations in hematological cancers, where the most conspicuous position
Protein Dis, 1(2):147.
https://doi.org/10.36922/gpd.v1i2.147 of several chromosomal translocations has drawn interest as a tumor suppressor.
In this paper, the malignancies triggered by RUNX1 mutations, which are strongly
Received: July 4, 2022 associated with cancers of the female reproductive system, along with their
Accepted: October 12, 2022
Published Online: November 2, 2022 diagnoses and potential treatments, are reviewed. It has been found that RUNX1
mutation plays a pervasive function in female health, including sex determination,
Copyright: © 2022 Author(s).
This is an Open Access article follicular development, steroidogenesis, and the interaction of the estrogen system.
distributed under the terms of the In contrast, chromosomal translocations in the gene linked to RUNX1 mutation may
Creative Commons Attribution lead to severe malignancies in females. Breast, ovarian, uterine, and cervical cancers
License, permitting distribution,
and reproduction in any medium, have shown the highest frequency of genetic abnormalities in the RUNX1 gene. The
provided the original work is second most common cause of cancer-related mortality in women is breast cancer,
properly cited. which is also the most common cancer. There is an opposing relationship between
Publisher’s Note: AccScience uterine cancer and low-grade tumors that often remain confined to the uterus. Due
Publishing remains neutral with to the regular occurrence of promoter hypermethylation and hypomethylation
regard to jurisdictional claims in
published maps and institutional changes, ovarian cancer has become the most fatal of all gynecological tumors.
affiliations. Finally, despite being the cancer least likely to result from RUNX1 mutation, cervical

Volume 1 Issue 2 (2022) 1 https://doi.org/10.36922/gpd.v1i2.147