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Gene & Protein in Disease DNA methylation and gene expression on rats with protein malnutrition

and Promotion of Special Science and Technology 2019, Protein restriction in early life increases intracellular
Project (No. 222102310587) and Science and Technology calcium and insulin secretion, but does not alter expression
Development Plan of Henan Province in 2021 of SNARE proteins during pregnancy. Exp Physiol, 104(7):
(No. 192102310517). 1029–1037.
https://doi.org/10.1113/EP087045
Conflict of interest
5. Loche E, Ozanne SE, 2016, Early nutrition, epigenetics, and
The authors declare no competing interests. cardiovascular disease. Curr Opin Lipidol, 27(5): 449–458.
Author contributions https://doi.org/10.1097/MOL.0000000000000338

Conceptualization: Zhi Qu and Bo Li 6. De Vasconcelos Barros MA, de Brito Alves JL, Barros RGN,
Formal analysis: Zhi Qu, Liying Fu, Chenchen Wang, and et al., 2020, Effects of maternal protein restriction on central
and peripheral renin-angiotensin systems in male rat
Suting Liu offspring. Life Sci, 263: 118574.
Funding acquisition: Zhi Qu and Bo Li
Investigation: Zhi Qu, Liying Fu, Chenchen Wang, and https://doi.org/10.1016/j.lfs.2020.118574
Suting Liu 7. Fesser EA, Gianatiempo O, Berardino BG, et al., 2021, Limited
Supervision: Zhi Qu and Bo Li contextual memory and transcriptional dysregulation in the
Writing – original draft: Zhi Qu, Liying Fu, Chenchen medial prefrontal cortex of mice exposed to early protein
Wang, Suting Liu, and Bo Li malnutrition are intergenerationally transmitted. J Psychiatr
Writing – review & editing: Zhi Qu and Bo Li Res, 139: 139–149.
https://doi.org/10.1016/j.jpsychires.2021.05.041
Ethics approval and consent to participate
8. Fernandez-Twinn DS, Constância M, Ozanne SE, 2015,
The study was reviewed and approved by the Ethics Intergenerational epigenetic inheritance in models of
Committee of Medicine and Scientific Research of Henan developmental programming of adult disease. Semin Cell
University (HUSOM-2019-112). Dev Biol, 43: 85–95.

Consent for publication https://doi.org/10.1016/j.semcdb.2015.06.006
Not applicable. 9. Yuasa K, Kondo T, Nagai H, et al., 2016, Maternal protein
restriction that does not have an influence on the birthweight
Availability of data of the offspring induces morphological changes in kidneys
reminiscent of phenotypes exhibited by intrauterine growth
Source data are provided with this paper. retardation rats. Cong Anom, 56(2): 79–85.

References https://doi.org/10.1111/cga.12143
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