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Gene & Protein in Disease DNA methylation and gene expression on rats with protein malnutrition

A B

C

Figure 15. Scatter plot of KEGG enrichment of methylation levels. (A) is for early-life low-protein group (LPE) versus control group (CON); (B) is for fetal
low-protein group (LPF) versus CON; and (C) is for LPF versus LPE.

expressed in rats at the early stage of life compared with and treatment of a variety of diseases. However, the genes
malnourished rats during pregnancy. Therefore, whether with significant differences excavated in this study are
the methylation of MT-ND (1, 2, 3, 4L, 4, 5, and 6) gene is rarely reported. According to the KEGG pathway and GO
associated with frontotemporal lobe degeneration diseases enrichment analysis, they must be related to the occurrence
deserves further exploration. and development of later diseases, which also opens up
new prospects for future experimental research.
5. Conclusion Whole-genome DNA methylation sequencing was
Malnutrition in early life can regulate the expression of performed on the whole blood of the offspring rats of the
genes related to endocrine metabolism, inflammatory LPE and LPF groups, and it was found that there were
factors, immune function, viral response, and signal significant differences in the methylation sites and levels of
transduction, thus regulating the body’s metabolism, the genes, especially the mitochondrial genes.
cell proliferation, division, apoptosis, and inflammatory Acknowledgments
response. The previous studies have proven that genetic
mutations caused by malnutrition in early life are closely None.
related to the occurrence of chronic diseases, such as
cardiovascular disease, kidney disease, and neurological Funding
disease in adulthood, which indicate that exploring This work was supported by Henan Science and
genetic changes provide a new direction for the diagnosis Technology Department Key Research and Development

Volume 1 Issue 2 (2022) 19 https://doi.org/10.36922/gpd.v1i2.169