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Gene & Protein in Disease Prognostic potential of LMNB2 in LPS

A

B
C

Figure 7. Immuno-infiltration analysis and correlation analysis of immunological checkpoints. (A) Differences in infiltration levels of 22 types of immune
cells between LMNB2 high and low expression groups. (B) Volcano Plot of infiltration levels. (C) Correlation analysis between immune checkpoint gene
and LMNB2 expression.

In Figure 7, the length of the line represents the correlation and DDLPS exhibit low sensitivity to chemotherapy and
between the immune checkpoint gene and LMNB2 radiotherapy. Hence, targeted therapy is preferred for
expression, while the size of the node represents the size of these two subtypes of LPS. The local recurrence and
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the P-value. Green nodes represent a P-value <0.05, while metastasis rate of PLPS ranges from 30% to 50%, and it
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red nodes represent a P > 0.05. As shown in Figure 7C, is usually insensitive to chemotherapy and radiotherapy,
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the expression of stimulating molecules such as BTNL3, with a mortality rate is up to 50%. In summary, due
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CD226, CD27, CD40LG, CD80, CD86, ICOS, to differences in clinical manifestation, drug sensitivity,
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TNFRSF14, TNFRSF18, or TNFRSF18 is negatively and recurrence tendency, there is an urgent need for
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correlated with the expression of LMNB2, showing a strong more effective treatment methods. 2,53,55 The treatment
correlation and statistical significance. Conversely, the of advanced or metastatic LPS remains a challenge for
expression of the inhibitory molecule VTCN1 positively researchers. At present, the commonly used treatment
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correlates with LMNB2. Therefore, we speculate that the for LPS includes local surgical resection combined with
poor prognosis of patients with high LMNB2 expression drug therapy (doxorubicin, ifosfamide, doxorubicin, etc.);
may be related to lower expression of stimulatory molecules yet, the response rate is usually low, and the duration of the
and higher expression of inhibitory molecules. response is usually short, which limits the efficacy. 57
4. Discussion At present, there is a lack of studies on the expression
and mechanism of LMNB2 in LPS. Previous studies
Due to the heterogeneity of LPS, the recurrence rate have primarily focused on LMNB1, and changes in the
exceeds 80%, while the mortality rate varies with the
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prognosis depending on the histological subtype. As the expression level of LMNB1 have been found to have
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different effects on different types of tumors.
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second most common subtype of LPS, MLPS accounts
for about 15 – 20% of LPS cases with higher recurrence. In this study, we evaluated the correlation between
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DDLPS, known for its high invasiveness, presents a high LMNB2 expression and immune cell infiltration in LPS
recurrence rate and a 5-year survival rate of 30%. WDLPS patients. The results revealed that the infiltration level of
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Volume 3 Issue 1 (2024) 10 https://doi.org/10.36922/gpd.2607