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Gene & Protein in Disease Prognostic potential of LMNB2 in LPS

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Figure 5. Gene ontology (GO) enrichment analysis of coexpressed genes of LMNB2. (A) The gene–gene interaction network among genes related to
LMNB2. (B) The top 10 predicted protein-protein interactions related to LMNB2. (C-F) Bubble plot and gene-concept network of BP, MF, CC, and KEGG
enrichment analysis, respectively.
Abbreviations: BP: Biological process; CC: Cell component; KEGG: Kyoto Gene and Genome Encyclopedia; MF: Molecular function.

function of LMNB2 in the BP is to participate in cysteine A total of 176 gene sets were found to be enriched, with
endopeptidase activity and apoptosis process. 56 gene sets showing enrichment in the group exhibiting
high expression of LMNB2 (Figure 6B). It was found that
3.5. LMNB2 gene set enrichment analysis the gene sets enriched in the high expression group include
To further explore the mechanism of LMNB2 in LPS “cell cycle” (Normalized enrichment score [NES] = 1.984,
progression, we used expression profile data of DDLPS P < 0.0001) and “oocyte meiosis” (NES = 1.870, P = 0.006),
patients for single-gene enrichment analysis (Figure 6A). which are closely associated with the progression of LPS

Volume 3 Issue 1 (2024) 8 https://doi.org/10.36922/gpd.2607