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Gene & Protein in Disease Prognostic potential of LMNB2 in LPS

“CD8+T cell” was higher in the low expression group of including phosphorylation, citrullination and sumoylation,
LMNB2. In addition, LMNB2 showed strong correlations has been implicated in LPS. 68-71 Thus, we postulated that
with immune stimulators (including ULBP1, TNFRSF14, the effects of histone modifications related to LMNB2 on
CD40L, and ENTPD1) (Figure 7). These results offer LPS might be correlated with LPS progression and act as a
valuable insights into relevant potential targets for future promoting factor to the development of LPS.
immune drug development.
Enrichment analysis of expression profile data of LPS 5. Conclusion
patients indicated that high expression of LMNB2 was Our study has identified elevated LMNB2 expression levels
consistent with the upregulation of E2F7 and E2F8 of E2F as a risk factor for the poor prognosis of LPS patients.
family members. The E2F family plays a crucial role in These findings contribute to a better understanding of the
the regulation of cell proliferation, differentiation, and mechanism of LPS progression, suggesting that LMNB2
apoptosis and is closely related to the occurrence of a variety could serve as a promising biomarker and potential
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7
of tumors, including cervical cancer, 60-62 prostate cancer, and therapeutic target for clinical treatment of LPS.
glioblastoma. Conversely, low expression of LMNB2 was
63
consistent with the upregulation of CD27. CD27, on binding Acknowledgments
with CD70, obtains co-stimulatory signals that enhance the None.
activation, survival, proliferation, and differentiation of T
cells, thereby supporting the maintenance of host defense Funding
function. Certain studies have indicated that patients This work was supported by the Program for Science
64
with CD27 deficiency are significantly more susceptible and Technology Development in Henan Province
to malignant tumors. Therefore, we speculate that the (No.212102310616) and the Innovation Project for
occurrence of LPS may also be related to the decrease of College Students of Henan University (Nos. 20237003002;
immune function resulting from the low expression of CD27.
20237003003; 202310475091).
In tumors, one reason for the failure of immune control
is the inhibition of effective function in infiltrating T cells. Conflict of interest
65
The upregulation of programmed cell death-1 (PD-1) on The authors declare no conflicts of interest.
+
CD8 T cells has emerged as a primary marker of T cell
dysfunction. The anti-human PD-1/PD ligand 1 (PD-L1) Author contributions
monoclonal antibody has witnessed widespread use in Conceptualization: Yang An
both clinical practice research on tumors and infectious
diseases. At present, the combination of PD-1 and cytotoxic Data curation: Man Yue, Mengwen Hou
T-lymphocyte-associated protein 4 (CTLA-4) with an Formal analysis: Xinyu Li, Jialin Wu, Kaifeng Zhang,
immune checkpoint blocker has entered clinical practice Tinggai Wu, Ting Ye
for treating patients with sarcomas. Compared with Investigation: Tiantian Sun, Xu Han, Guangchao Liu
immune checkpoint blockers alone, the response rate of Methodology Jiayang Han, Binbin Zhao
patients receiving combined immune checkpoint blockers Validation: Man Yue, Mengwen Hou, Mengjie Tu
is significantly improved. Therefore, for the treatment Writing—original draft: Xinyu Li, Jialin Wu, Yang An
66
of LPS, combining PD-1 and CTLA-4 with an immune Writing—review & editing: Yang An.
checkpoint blocker might offer a relatively reliable method. Ethics approval and consent to participate
This study focused on LMNB2, exploring its function and
pathways in regulating LPS progression. Not applicable.

As mentioned previously, the most enriched functions Consent for publication
of LMNB2 in BPs are “aging” and “histone modification.”
The main function of LMNB2 is to maintain the integrity of Not applicable.
the nucleoskeleton by affecting chromosome distribution, Availability of data
which is involved in cell proliferation and senescence.
67
Thus, we postulated that high expression of LMNB2 is Publicly available datasets were analyzed in this study. The
associated with the inhibition of LPS cell senescence. datasets analyzed for this study can be found in the TCGA
However, the specific pathways by which LMNB2 mediate database (https://www.cancer.gov/about-nci/organization/
LPS tumor cell senescence are not known. It is widely ccg/research/structuralgenomics/tcga) and GEO database
acknowledged that a wide variety of histone modifications, (https://www.ncbi.nlm.nih.gov/gds/?term=).

Volume 3 Issue 1 (2024) 11 https://doi.org/10.36922/gpd.2607