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Gene & Protein in Disease Bioinformatics to identify gene signatures of CF
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Figure 6. Module analysis of protein-protein interaction network. (A) Module 1 has 13 nodes with 55 edges. (B) Module 2 has eight nodes and 12
connections.
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Figure 7. Protein-protein interaction (PPI) network used for discovering hub genes. The six highlighted nodes represent the hub genes. CytoHubba’s
degree score technique takes into account 94 nodes from the combined PPI network.
Table 2. Topological characteristics for the five molecular genes of the PPI network
Gene signature name Degree Betweenness centrality Clustering coefficient Closeness centrality Stress
RNASEL 56.462 124,079 56 55 0.17013
CUL1 53.17 39,940 38 38 0.21195
CDC42 50.534 586 36 34 0.15873
HDAC4 48.957 678 30 30 0.2023
UBA2 50.98 68,772 30 30 0.3195
WWP2 23 350.8 39 86.5 0.3014
Abbreviation: PPI: Protein-protein interaction.
Volume 3 Issue 2 (2024) 7 doi: 10.36922/gpd.2937
