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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Figure 2. Correlation between CALCA, SERPINE1, MMP13, and SPP1 in oral squamous cell carcinoma (The Cancer Genome Atlas). Data were extracted
from the TIMER web server. P < 0.05 was considered statistically significant
Abbreviations: cor: Correlation; TPM: Transcripts per million.

Notably, previous studies have demonstrated that, the CLOCK gene in an animal model resulted in
although breast cancer patients have lower serum diminished metastatic capacity. In vitro analyses further
melatonin levels than healthy individuals, higher demonstrated that elevated expression of the human
melatonin levels are associated with metastasis CLOCK gene in colorectal cancer cell lines induced
development in the distal organ. Wang et al. analyzed epithelial-mesenchymal transition and activated
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tissue specimens of patients with colorectal cancer and angiogenic genes. On the other hand, downregulation
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showed that overexpression of the circadian locomotor of PER1 has been observed in primary tumor samples
output cycles kaput (CLOCK) gene was associated with from patients with OSCC. In this study, we identified
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metastatic development in lymph nodes. Silencing dysregulation of circadian rhythm genes in metastatic
Volume 3 Issue 4 (2024) 18 doi: 10.36922/gpd.2971