Page 110 - GPD-3-4

Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 4. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa04612: Antigen 1.1820331 1.42E-04 HLA‑DQB1, KLRC2, HLA‑DRB1, 2.24578667 0.02573915 0.00144763 0.17504864
processing and CD8A, CD8B, HLA‑DRB3,
presentation HLA‑DMB, HLA‑DMA, RFXAP,
CD74, CD4, HLA‑DOA,
HLA‑DOB, LTA, CIITA,
RFX5, CREB1, CTSS, HLA‑E,
HLA‑DQA2, HLA‑G, HLA‑DQA1,
HLA‑F, HLA‑DPA1, HLA‑DRA
hsa04630: Jak-STAT 1.79669031 2.34E-04 CSF3, STAT5A, STAT5B, IL21R, 1.82792546 0.04214707 0.0022638 0.28890247
signaling pathway IL15, IL7R, IL11, STAT4, IL12RB1,
IL23A, IL4R, IL10RA, PIK3CA,
IL2RG, PIK3R5, AKT3, CSF2RA,
GHR, AKT2, PIK3CG, PTPN6,
IL2RB, IL23R, IL5, IL7, PIK3CD,
CREBBP, IL6R, TSLP, IFNAR2,
CBLB, EP300, CCND3, PIAS4,
CCND2, IL12A, JAK2, IL3RA
hsa05416: Viral 1.04018913 2.59E-04 HLA‑DQB1, ITGAL, HLA‑DRB1, 2.31031349 0.0465486 0.0023805 0.31975393
myocarditis HLA‑DRB3, CD40, HLA‑DMB,
HLA‑E, HLA‑DQA2, HLA‑DMA,
HLA‑DQA1, HLA‑G, HLA‑F,
RAC2, CASP9, CD40LG, FYN,
MYH11, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, CD28, HLA‑DRA
hsa04210: Apoptosis 1.1820331 3.12E-04 PIK3CG, TNF, DFFB, PIK3CD, 2.14253211 0.05587998 0.00273444 0.3856018
TP53, FASLG, NFKB1, BIRC3,
ATM, IRAK4, TNFRSF10A,
PRKAR2B, TNFRSF10B, CASP9,
RIPK1, IKBKG, PRKAR1A,
PPP3CB, PIK3CA, EXOG, PIK3R5,
MAP3K14, IL3RA, AKT3, AKT2
hsa04070: 1.04018913 4.84E-04 PRKCA, PIK3CG, PIK3C2G, 2.21665214 0.08514472 0.0040368 0.59612239
Phosphatidylinositol PIK3C2B, PIK3CD, PIP5K1B,
signaling system ITPKB, PIP5K1A, ITPR1,
PRKCB, DGKA, DGKB, PLCG1,
PIKFYVE, PLCG2, PIK3CA,
PIK3R5, INPP4B, INPP5D,
INPP4A, PIP4K2A, PLCB2
hsa05221: Acute 0.85106383 0.00110129 PIK3CG, TCF7, BRAF, FLT3, 2.31393467 0.18351616 0.0087764 1.35299791
myeloid leukemia STAT5A, STAT5B, PIK3CD, LEF1,
NFKB1, PIM2, KIT, MAPK1,
KRAS, IKBKG, PIK3CA, PIK3R5,
AKT3, AKT2
hsa04270: Vascular 1.32387707 0.0013631 GNA13, ADCY4, ADCY1, ADCY7, 1.86400293 0.22196387 0.01040311 1.67217376
smooth muscle ADORA2A, PPP1R12B, MRVI1,
contraction PLCB2, PRKCA, RAMP3, RAMP2,
ARHGEF1, ROCK1, BRAF,
PRKCH, NPR1, NPR2, ITPR1,
PRKCB, SPDYA, MAPK1, PRKCQ,
PLA2G4A, AVPR1A, MYH11,
GUCY1B3, CACNA1F, PLA2G2D
hsa04670: Leukocyte 1.37115839 0.00144942 ITGAL, SIPA1, CLDN5, MMP2, 1.83240966 0.23424074 0.01061872 1.77719479
transendothelial CXCL12, VCAM1, RAC2, CXCR4,
migration PIK3CA, ESAM, PIK3R5, RHOH,
PRKCA, PIK3CG, ITK, ROCK1,
NCF1, NCF4, PIK3CD, ITGA4,
VAV1, PRKCB, RASSF5, CYBB,
PLCG1, PLCG2, RAP1A, TXK, JAM2
(Cont’d...)

Volume 3 Issue 4 (2024) 13 doi: 10.36922/gpd.2971