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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 4. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa05330: Allograft 1.04018913 2.68E-10 HLA‑DQB1, TNF, IL5, HLA‑DRB1, 4.55645161 4.93E-08 9.85E-09 3.31E-07
rejection HLA‑DRB3, FASLG, GZMB, CD40,
HLA‑DMB, HLA‑E, HLA‑DQA2,
HLA‑DMA, HLA‑DQA1,
HLA‑G, HLA‑F, CD40LG,
IL12A, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, CD28, HLA‑DRA
hsa04672: Intestinal 1.1820331 1.77E-09 HLA‑DQB1, IL5, HLA‑DRB1, 3.80408762 3.25E-07 5.41E-08 2.18E-06
immune network for HLA‑DRB3, TNFRSF17,
IgA production TNFSF12, ITGA4, CD40, IL15,
HLA‑DMB, HLA‑DQA2, CXCL12,
HLA‑DMA, HLA‑DQA1, CCR9,
CXCR4, CD40LG, ICOS, AICDA,
HLA‑DPA1, MAP3K14, HLA‑DOA,
HLA‑DOB, CD28, HLA‑DRA
hsa04514: Cell 2.12765957 2.17E-09 HLA‑DQB1, ITGAL, CADM3, 2.54182218 3.99E-07 5.70E-08 2.68E-06
adhesion molecules HLA‑DRB1, CD8A, CD8B,
(CAMs) HLA‑DRB3, CLDN5, L1CAM,
HLA‑DMB, HLA‑DMA, VCAM1,
ICOS, CD2, CD22, ESAM, CD4,
HLA‑DOA, CD6, SELPLG,
HLA‑DOB, SPN, CD28, SELP,
PTPRC, SELL, ICAM2, ICAM3,
CTLA4, NFASC, CD276, ITGA4,
CD40, HLA‑E, HLA‑DQA2,
HLA‑G, HLA‑DQA1, HLA‑F,
CD40LG, CNTN2, HLA‑DPA1,
JAM2, SELE, CD226, HLA‑DRA
hsa04940: Type I 1.04018913 1.17E-08 HLA‑DQB1, ICA1, TNF, 3.90552995 2.15E-06 2.69E-07 1.44E-05
diabetes mellitus HLA‑DRB1, PTPRN2, HLA‑DRB3,
FASLG, GZMB, HLA‑DMB,
HLA‑E, HLA‑DQA2, HLA‑DMA,
HLA‑DQA1, HLA‑G, HLA‑F,
IL12A, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, LTA, CD28, HLA‑DRA
hsa04650: Natural 2.03309693 3.08E-08 ITGAL, CD244, KLRC2, MICA, 2.41059026 5.67E-06 6.30E-07 3.81E-05
killer cell-mediated TNF, CD247, KLRK1, FASLG,
cytotoxicity CD48, SH2D1A, KRAS, RAC2,
PPP3CB, ZAP70, PIK3CA, PIK3R5,
NFATC3, NFATC1, SYK, PIK3CG,
PRKCA, PTPN6, BRAF, ICAM2,
PIK3CD, GZMB, HLA‑E, VAV1,
HLA‑G, PRKCB, NCR3, HCST,
TNFRSF10A, MAPK1, LAT,
IFNAR2, TNFRSF10B, PLCG1,
FYN, ULBP1, LCK, PLCG2, LCP2
hsa04062: Chemokine 2.55319149 3.09E-08 ADCY4, ADCY1, ADCY7, PREX1, 2.15307291 5.68E-06 5.68E-07 3.81E-05
signaling pathway STAT5B, CXCR2, NFKB1, CXCL12,
CXCR5, CXCR4, PIK3CA, GNG2,
CSK, PLCB2, AKT3, GNG7, AKT2,
PIK3CG, ROCK1, BRAF, LYN,
NCF1, PIK3CD, PRKCB, CCR9,
MAPK1, CCR7, CCR4, CCR3,
CX3CR1, FGR, CXCL5, CXCL2,
PF4, CCL22, DOCK2, KRAS,
CCL20, RAC2, CCL21, RASGRP2,
PIK3R5, ITK, HCK, CCL19, VAV1,
CCL17, CCL14, CXCL13, IKBKG,
GRK6, RAP1A, JAK2, GRK5
(Cont’d...)
Volume 3 Issue 4 (2024) 11 doi: 10.36922/gpd.2971