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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 4. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa05211: Renal cell 0.75650118 0.04116203 PIK3CG, EPAS1, BRAF, VHL, 1.70423125 0.99956236 0.1681851 40.5267068
carcinoma ARNT2, CREBBP, PIK3CD,
MAPK1, EP300, KRAS, ETS1,
PIK3CA, RAP1A, PIK3R5, AKT3,
AKT2
hsa04620: Toll-like 0.9929078 0.04416942 PIK3CG, TNF, MAP2K4, 1.55025986 0.99975448 0.17576966 42.7921596
receptor signaling PIK3CD, NFKB1, CD40, TLR9,
pathway IRAK4, MAP3K7, MAPK1,
IFNAR2, RIPK1, MAP3K8,
IKBKG, IL12A, PIK3CA, PIK3R5,
IRF3, MAPK8, AKT3, AKT2
hsa04914: 0.85106383 0.06113686 ANAPC1, PIK3CG, ADCY4, 1.56056059 0.9999909 0.23188233 54.1551262
Progesterone- ADCY1, BRAF, ADCY7, PIK3CD,
mediated oocyte CDC26, SPDYA, MAPK1,
maturation RPS6KA3, KRAS, RPS6KA2,
PIK3CA, PIK3R5, MAPK8, AKT3,
AKT2
hsa04020: Calcium 1.51300236 0.06304285 ADCY4, ADCY1, ADCY7, 1.3556385 0.99999374 0.23375948 55.2925417
signaling pathway CYSLTR1, ADORA2A, TACR1,
ITPKB, ATP2B1, ADRB3, EDNRB,
ATP2B3, PPP3CB, PLCB2,
PRKCA, PHKG1, CACNA1I,
NTSR1, PTGFR, ITPR1, PRKCB,
P2RX5, P2RX4, CAMK4, PLCG1,
ATP2A3, CHRM1, PLCG2,
AVPR1A, CACNA1H, CACNA1F,
HTR2C, CACNA1A
hsa05120: Epithelial 0.70921986 0.06349031 LYN, MAP2K4, CXCR2, 1.64470847 0.99999427 0.2307826 55.5557812
cell signaling in ATP6V1G2, NFKB1, SRC,
Helicobacter pylori ATP6V1A, NOD1, PLCG1,
infection PLCG2, IKBKG, MAPK8,
MAP3K14, CSK, JAM2
hsa05322: Systemic 0.94562648 0.06406557 HLA‑DQB1, C7, TNF, HLA‑DRB1, 1.506265 0.99999488 0.22833484 55.8921103
lupus erythematosus HLA‑DRB3, C6, CD40, HLA‑DMB,
HLA‑DQA2, HLA‑DMA,
HLA‑DQA1, FCGR2B, GRIN2B,
CD40LG, HIST1H4F, HLA‑DPA1,
HLA‑DOA, HLA‑DOB, CD28,
HLA‑DRA
hsa05214: Glioma 0.66193853 0.07095087 PRKCA, PIK3CG, BRAF, PIK3CD, 1.6568915 0.99999868 0.24580854 59.7401318
TP53, PRKCB, MAPK1, KRAS,
PLCG1, PLCG2, PIK3CA,
PIK3R5, AKT3, AKT2
hsa04150: mTOR 0.56737589 0.07964231 PIK3CG, MAPK1, RPS6KA3, 1.72061809 0.99999977 0.26775988 64.1567476
signaling pathway BRAF, RPS6KA2, PIK3CD,
PIK3CA, PIK3R5, PRKAA1,
RPTOR, AKT3, AKT2
hsa05216: Thyroid 0.37825059 0.08317434 MAPK1, TCF7, KRAS, BRAF, 2.05683082 0.99999988 0.27353403 65.8206999
cancer NCOA4, RXRB, TP53, LEF1
Note: P<0.05 was considered statistically significant.
Abbreviations: FDR: False discovery rate; MAPK: mitogen-activated protein kinase; mTOR: mammalian target of rapamycin;
VEGF: Vascular endothelial growth factor.

Volume 3 Issue 4 (2024) 16 doi: 10.36922/gpd.2971