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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 4. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa04370: VEGF 0.9929078 0.00153595 PRKCA, PIK3CG, PIK3CD, 2.08768328 0.24635315 0.01081918 1.8823596
signaling pathway SRC, KDR, PRKCB, MAPK1,
PLA2G4A, KRAS, PLCG1,
RAC2, CASP9, PLCG2, PPP3CB,
PIK3CA, PIK3R5, PLA2G2D,
NFATC3, AKT3, NFATC1, AKT2
hsa05215: Prostate 1.08747045 0.00263771 PIK3CG, FGFR1, TCF7, BRAF, 1.92683449 0.38490568 0.01783823 3.21249119
cancer CREB1, CREBBP, PIK3CD, TP53,
LEF1, FOXO1, NFKB1, CCNE2,
MAPK1, KRAS, CDKN1B, EP300,
CASP9, IKBKG, PIK3CA, PIK3R5,
PDGFD, AKT3, AKT2
hsa05220: Chronic 0.94562648 0.00375763 PIK3CG, BCR, BRAF, STAT5A, 1.98826979 0.49977907 0.02443597 4.54753719
myeloid leukemia STAT5B, PIK3CD, TP53, SMAD4,
NFKB1, MECOM, MAPK1,
ACVR1B, CBLB, KRAS, CDKN1B,
IKBKG, PIK3CA, PIK3R5, AKT3,
AKT2
hsa05200: Pathways in 2.88416076 0.00575604 FGF5, STAT5A, ARNT2, 1.38663633 0.65429531 0.03596393 6.88786138
cancer STAT5B, FOXO1, FASLG,
NFKB1, NFKB2, MMP2,
FLT3LG, CCNE2, ACVR1B,
CASP9, PIK3CA, AKT3,
CSF2RA, AKT2, PRKCA,
PIK3CG, BCR, BRAF, RXRB,
PIK3CD, TP53, LEF1, MECOM,
STK4, PRKCB, MAPK1, EP300,
PIAS4, NCOA4, MAPK8,
TRAF1, FGFR1, WNT16, KIT,
KRAS, RAC2, PIK3R5, AXIN2,
TRAF5, COL4A4, FZD8, TCF7,
EPAS1, VHL, FLT3, CREBBP,
SMAD4, APPL1, BIRC3, FZD4,
RASSF5, CBLB, CDKN1B,
PLCG1, ETS1, IKBKG, PLCG2,
PTCH2
hsa04722: 1.32387707 0.00627781 NFKBIE, FASLG, NFKB1, 1.68361555 0.68612434 0.03788883 7.49016567
Neurotrophin IRAK4, KRAS, MAP3K3, SH2B3,
signaling pathway PIK3CA, PIK3R5, SH2B2,
CSK, AKT3, ARHGDIB, AKT2,
PIK3CG, BRAF, PIK3CD, TP53,
RPS6KA5, MAPK1, RPS6KA3,
CAMK4, PLCG1, RPS6KA2,
PLCG2, RAP1A, MAPK8, NGFR
hsa05210: Colorectal 0.9929078 0.00636178 PIK3CG, FZD8, TCF7, BRAF, 1.86400293 0.69096704 0.03717238 7.58676142
cancer PIK3CD, TP53, SMAD4, LEF1,
APPL1, FZD4, MAPK1, ACVR1B,
KRAS, RAC2, CASP9, PIK3CA,
PIK3R5, MAPK8, AXIN2, AKT3,
AKT2
hsa00562: Inositol 0.70921986 0.00976227 PIK3CG, PIK3C2G, PIK3C2B, 2.07111437 0.83553906 0.05484734 11.4214764
phosphate metabolism PIK3CD, PIP5K1B, ITPKB,
PIP5K1A, PLCG1, PIKFYVE,
PLCG2, PIK3CA, INPP4B,
INPP4A, PIP4K2A, PLCB2
(Cont’d...)

Volume 3 Issue 4 (2024) 14 doi: 10.36922/gpd.2971