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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 3. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa00010: 0.71157495 0.02094904 ALDOA, LDHA, HK2, FBP1, PFKP, 1.900224215 0.978788841 0.348277506 22.9920687
Glycolysis/ PGAM2, ALDH3B2, BPGM, ADH7, PGM2,
Gluconeogenesis ALDH7A1, TPI1, ALDH1A3, HK3, ENO1
hsa04144: 1.66034156 0.02255403 FGFR2, PARD3, FGFR4, HRAS, CLTB, 1.445822772 0.984264428 0.339780642 24.5355185
Endocytosis FGFR3, LDLR, CHMP4C, ERBB3, ASAP2,
HSPA1A, ASAP3, HSPA1B, IGF1R,
HSPA2, HSPA6, NEDD4L, EGF, AGAP2,
SH3GL3, EGFR, EPN3, PLD1, DNM1L,
FLT1, RAB4A, PRKCI, PSD2, RAB31,
PSD, ACAP3, NEDD4, ACAP2, ARAP3,
CLTCL1, SH3GL1
hsa04530: Tight 1.28083491 0.02452481 CLDN8, HRAS, PARD3, OCLN, GNAI3, 1.531523994 0.989101832 0.336902192 26.3918352
junction ZAK, CLDN4, GNAI1, AMOTL1, LLGL1,
CTTN, YES1, PPP2R2C, F11R, MAGI2,
ACTN4, CNKSR3, PRKCI, ACTN1,
CTNNA1, NRAS, CGN, CLDN1, CLDN2,
RAB13, TJP2, MYH10
hsa00051: Fructose 0.4743833 0.0275831 ALDOA, TPI1, PFKFB4, AKR1B10, HK3, 2.2355579 0.993846036 0.345721104 29.1895597
and mannose PFKFB2, HK2, PFKP, FBP1, PMM2
metabolism
hsa04115: p53 0.75901328 0.0279472 STEAP3, RPRM, CDK6, CHEK1, SFN, 1.78844632 0.994251507 0.327553095 29.5160473
signaling pathway SESN3, EI24, CCND1, TP53I3, CDKN1A,
CDKN2A, SERPINB5, GADD45G,
SERPINE1, PERP, THBS1
hsa05216: Thyroid 0.42694497 0.02917712 NRAS, CCDC6, HRAS, CCND1, RXRA, 2.358899026 0.995434584 0.319512697 30.608716
cancer TFG, CDH1, TCF7L2, TCF7L1
hsa04960: 0.52182163 0.03566208 ATP1B1, SGK1, ATP1B3, HSD11B1, 2.039265011 0.9986519 0.356352414 36.1169647
Aldosterone- HSD11B2, NEDD4L, SCNN1G, SFN,
regulated sodium SCNN1B, INSR, SCNN1A
reabsorption
hsa05222: Small 0.85388994 0.04327485 COL4A2, RXRA, SKP2, ITGA2, CDK6, 1.628763613 0.999681383 0.395419278 42.0691502
cell lung cancer ITGA3, COL4A6, LAMA1, LAMB4,
CCND1, LAMA4, LAMB3, LAMA3, ITGA6,
CDKN2B, LAMC2, LAMC1, LAMB1
hsa00150: 0.4743833 0.04579641 AKR1C4, HSD17B2, HSD17B1, SRD5A3, 2.054296449 0.999802907 0.394604143 43.9253923
Androgen HSD11B1, HSD11B2, SULT2B1, UGT2A1,
and estrogen SRD5A1, SULT1E1
metabolism
hsa04810: 1.80265655 0.0479246 FGFR2, FGFR4, ENAH, HRAS, FGFR3, 1.343414329 0.999868724 0.391383657 45.4493499
Regulation of actin PDGFA, WASF1, BCAR1, DIAPH
cytoskeleton 3, ITGB4, FGF10, ITGB5, BDKRB1,
BDKRB2, ITGAM, PAK6, PFN2, RAC3,
ITGB6, RAC1, EGF, EGFR, LIMK2,
ACTN4, BAIAP2, ITGA2, ACTN1, ITGA3,
FGF21, NCKAP1, NRAS, CRKL, CHRM3,
ITGA6, CYFIP1, WASL, CD14, MYH10
hsa04012: ErbB 0.85388994 0.05773379 EGFR, HRAS, NRG4, ERBB3, ERBB2, 1.572599351 0.999980066 0.434268405 51.9938358
signaling pathway PAK6, NRAS, CDKN1A, EIF4EBP1,
CRKL, JUN, HBEGF, TGFA, AREG,
NRG1, EGF, ABL2, NRG2

(Cont’d...)

Volume 3 Issue 4 (2024) 9 doi: 10.36922/gpd.2971