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Gene & Protein in Disease Pre-metastatic niche oral cancer: Insights

Table 4. (Continued)
Term % P‑value Genes Fold Bonferroni Benjamini FDR
enrichment
hsa05310: Asthma 0.75650118 8.65E-07 HLA‑DQB1, FCER1A, TNF, 4.11366164 1.59E-04 1.45E-05 0.0010698
IL5, HLA‑DRB1, HLA‑DRB3,
CD40, HLA‑DMB, HLA‑DMA,
HLA‑DQA2, HLA‑DQA1,
CD40LG, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, HLA‑DRA
hsa04060: 3.02600473 1.16E-06 IL21R, FASLG, CXCR2, IL15, 1.82131584 2.13E-04 1.77E-05 0.00142939
Cytokine-cytokine TNFSF12, CXCL12, IL11,
receptor interaction FLT3LG, ACVR1B, TNFRSF11B,
CXCR5, CXCR4, IL4R, LTB,
LTA, CSF2RA, GHR, TNFRSF17,
TNFRSF14, IL6R, CD40, CCR9,
TNFRSF10A, IFNAR2, TNFRSF9,
CCR7, TNFRSF10B, RELT, CCR4,
CD40LG, CCR3, CX3CR1, IL12A,
NGFR, CSF3, TNF, CXCL5,
TNFRSF25, CXCL2, TNFRSF8,
PF4, KIT, IL7R, CCL22,
TNFRSF1B, IL23A, IL12RB1,
CCL20, CCL21, IL10RA, IL2RG,
CD27, IL2RB, IL23R, IL5, IL7,
FLT3, CCL19, KDR, CCL17,
TSLP, CCL14, CXCL13, IL3RA
hsa04664: Fc epsilon 1.32387707 1.28E-06 TNF, BTK, KRAS, RAC2, PIK3CA, 2.67651703 2.36E-04 1.81E-05 0.00158281
RI signaling pathway PIK3R5, INPP5D, AKT3, AKT2,
SYK, PRKCA, PIK3CG, FCER1A,
IL5, LYN, PIK3CD, MAP2K4,
VAV1, PRKCB, MAPK1, LAT,
PLA2G4A, PLCG1, FYN, PLCG2,
MAPK8, PLA2G2D, LCP2
hsa05332: 0.85106383 3.39E-06 HLA‑DQB1, TNF, HLA‑DRB1, 3.44123618 6.24E-04 4.46E-05 0.00419502
Graft-versus-host HLA‑DRB3, FASLG, GZMB,
disease HLA‑DMB, HLA‑E, HLA‑DQA2,
HLA‑DMA, HLA‑DQA1, HLA‑G,
HLA‑F, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, CD28, HLA‑DRA
hsa05320: 0.9929078 3.46E-06 HLA‑DQB1, IL5, HLA‑DRB1, 3.07012248 6.36E-04 4.24E-05 0.00427531
Autoimmune thyroid HLA‑DRB3, CTLA4, FASLG,
disease GZMB, CD40, HLA‑DMB,
HLA‑E, HLA‑DQA2, HLA‑DMA,
HLA‑DQA1, HLA‑G, HLA‑F,
CD40LG, HLA‑DPA1, HLA‑DOA,
HLA‑DOB, CD28, HLA‑DRA
hsa04666: Fc 1.37115839 2.73E-05 MARCKSL1, PIP5K1B, ARPC4, 2.27604569 0.0050155 3.14E-04 0.0337775
gamma R-mediated PIP5K1A, DOCK2, RAC2,
phagocytosis PIKFYVE, PIK3CA, PIK3R5,
INPP5D, AKT3, SYK, AKT2,
PRKCA, PIK3CG, PTPRC, LYN,
NCF1, HCK, PIK3CD, VAV1,
PRKCB, MAPK1, LAT, PLA2G4A,
PLCG1, FCGR2B, CFL2, PLCG2
hsa05223: Non-small 0.89834515 1.34E-04 PRKCA, PIK3CG, FHIT, BRAF, 2.62341153 0.02430181 0.00144613 0.16516041
cell lung cancer RXRB, PIK3CD, TP53, STK4,
PRKCB, MAPK1, RASSF5, KRAS,
PLCG1, CASP9, PLCG2, PIK3CA,
PIK3R5, AKT3, AKT2
(Cont’d...)

Volume 3 Issue 4 (2024) 12 doi: 10.36922/gpd.2971