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Gene & Protein in Disease FXR1 modulates gene expression in cancer

Such investigations will provide deeper insights into the Availability of data
functional role of FXR1 in cancer biology and its potential
as a therapeutic target. All data generated or analyzed during this study are
included in this published article and are available upon
5. Conclusion request from the corresponding author.
The present investigation demonstrates a strong association References
between alterations in FXR1 activity and the expression 1. Re A, Joshi T, Kulberkyte E, Morris Q, Workman CT.
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suppressors highlights its potential as a diagnostic doi: 10.1007/978-1-62703-709-9_23
marker and therapeutic target in cancer. While our study 2. Gerstberger S, Hafner M, Tuschl T. A census of human
provides novel insights into the regulatory functions of RNA-binding proteins. Nat Rev Genet. 2014;15(12):829-845.
FXR1, further research is necessary to fully elucidate the doi: 10.1038/nrg3813
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mRNAs in various cancers. Future investigations will pave 3. Pereira B, Billaud M, Almeida R. RNA-binding proteins
in cancer: Old players and new actors. Trends Cancer.
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tools and targeted therapies aimed at mitigating FXR1’s
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4. Hentze MW, Castello A, Schwarzl T, Preiss T. A brave new
Acknowledgments world of RNA-binding proteins. Nat Rev Mol Cell Biol.

None. 2018;19(5):327-341.
doi: 10.1038/nrm.2017.130
Funding
5. Khan FA, Fang N, Zhang W, Ji S. The multifaceted role of
This work was supported by the National Natural Science fragile X-related protein 1 (FXR1P) in cellular processes:
Foundation of China (No.31371386) and the Natural An updated review on cancer and clinical applications. Cell
Science Foundation of Henan Province (No.162300410042). Death Dis. 2024;15(1):72.
doi: 10.1038/s41419-023-06413-8
Conflict of interest
6. Bechara E, Davidovic L, Melko M, et al. Fragile X related
Xin-Ying Ji is an Editorial Board Member of this journal protein 1 isoforms differentially modulate the affinity of
but was not involved in the editorial and peer-review fragile X mental retardation protein for G-quartet RNA
process conducted for this paper, directly or indirectly. structure. Nucleic Acids Res. 2007;35(1):299-306.
Other authors declared that they have no known competing doi: 10.1093/nar/gkl1021
financial interests or personal relationships that could have
influenced the work reported in this paper. 7. Schaeffer C, Bardoni B, Mandel JL, Ehresmann B,
Ehresmann C, Moine H. The fragile X mental retardation
Author contributions protein binds specifically to its mRNA via a purine quartet
motif. EMBO J. 2001;20(17):4803-4813.
Conceptualization: Xin-Ying Ji, Shaoping Ji, Jingcheng doi: 10.1093/emboj/20.17.4803
Dong
Formal analysis: Faiz Ali Khan 8. Vasudevan S, Steitz JA. AU-rich-element-mediated
Investigation: Faiz Ali Khan upregulation of translation by FXR1 and Argonaute 2. Cell.
Methodology: Faiz Ali Khan 2007;128(6):1105-1118.
Supervision: Xin-Ying Ji, Shaoping Ji, Jingcheng Dong doi: 10.1016/j.cell.2007.01.038
Writing – original draft: Faiz Ali Khan 9. Darnell JC, Fraser CE, Mostovetsky O, Darnell RB.
Writing – review & editing: Faiz Ali Khan Discrimination of common and unique RNA-binding
activities among Fragile X mental retardation protein
Ethics approval and consent to participate paralogs. Hum Mol Genet. 2009;18(17):3164-3177.
Not applicable. doi: 10.1093/hmg/ddp255

Consent for publication 10. Tamanini F, Willemsen R, van Unen L, et al. Differential
expression of FMR1, FXR1 and FXR2 proteins in human
Not applicable. brain and testis. Hum Mol Genet. 1997;6(8):1315-1322.

Volume 4 Issue 1 (2025) 16 doi: 10.36922/gpd.5068