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Gene & Protein in Disease FXR1 modulates gene expression in cancer

A

Figure 7. Expression analysis of selected upregulated genes and their impact on overall survival (OS) in cancer. (A) The expression levels of the selected
upregulated genes and their association with OS were analyzed using The Cancer Genome Atlas datasets. Gene expression is depicted as box plots
comparing tumor and normal tissues (left panel), highlighting significant differences in expression. Kaplan-Meier survival curves (right panel) illustrate
the correlation between gene expression levels and overall patient survival across various cancer types, with statistical significance indicated. (B) FXR1
expression across different cancers was examined, with hazard ratios and p-values provided to assess the prognostic significance of its upregulation
concerning patient outcomes. (C) The most prevalent mutation of FXR1 in cancers is amplification. Note: * P < 0.05.
Abbreviation: DLBC: Diffuse large B cell lymphoma; ESCA: Esophageal cancer: GBM: Glioblastoma; LUAD: Lung adenocarcinoma; OV: Ovarian cancer;
TPM: Transcript per million.

Volume 4 Issue 1 (2025) 13 doi: 10.36922/gpd.5068