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Gene & Protein in Disease FXR1 modulates gene expression in cancer

Figure 8. Expression analysis of selected downregulated genes and their impact on overall survival (OS) in cancer. The expression levels of the selected
downregulated genes and their association with OS in various cancer types were analyzed using The Cancer Genome Atlas datasets. Gene expression
data are represented as box plots, comparing tumor and normal tissue samples (left panel). Kaplan-Meier survival curves were generated to assess the
correlation between gene expression and overall survival in specific cancer types, with hazard ratios and P-values provided to evaluate the prognostic
significance of each gene’s expression concerning patient survival outcomes. Note: *P < 0.05.
Abbreviation: DLBC: Diffuse large B cell lymphoma; ESCA: Esophageal cancer; GBM: Glioblastoma; TPM: Transcript per million.

overexpression may lead to a saturation effect, driving stress-sensitive mRNAs or delaying apoptosis through
FXR1 into stress granules and diminishing its regulatory a selective translation of pro-survival factors. Future
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activity. Interestingly, stress granule formation itself may studies are needed to elucidate the specific conditions
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contribute to cancer progression by facilitating cancer cell under which FXR1 transitions between active and
adaptation to stress. The sequestration of FXR1 into stress sequestered states and to understand how these dynamics
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granules could enhance cancer cell survival by protecting impact cancer progression and cellular stress adaptation.

Volume 4 Issue 1 (2025) 15 doi: 10.36922/gpd.5068