Page 25 - GPD-4-1
P. 25
Gene & Protein in Disease Gene fusions and chimeric RNAs
24. Egashira S, Jinnin M, Ajino M, et al. Chronic sun exposure- 35. Hernández-Torres F, Rastrojo A, Aguado B. Intron retention
related fusion oncogenes EGFR-PPARGC1A in cutaneous and transcript chimerism conserved across mammals:
squamous cell carcinoma. Sci Rep. 2017;7:12654. Ly6g5b and Csnk2b-Ly6g5b as examples. BMC Genomics.
2013;14:1-12.
doi: 10.1038/s41598-017-12836-z
doi: 10.1186/1471-2164-14-199
25. Holly JM, Broadhurst J, Mansor R, Bahl A, Perks CM.
Hyperglycemia promotes TMPRSS2-ERG gene fusion in 36. Akiva P, Toporik A, Edelheit S, et al. Transcription-mediated
prostate cancer cells via upregulating insulin-like growth gene fusion in the human genome. Genome Res. 2006;16:30-
factor-binding protein-2. Front Endocrinol (Lausanne). 36.
2017;8:305. doi: 10.1101/gr.4137606
doi: 10.3389/fendo.2017.00305 37. Qin F, Song Z, Babiceanu M, et al. Discovery of CTCF-
26. Eguchi-Ishimae M, Eguchi M, Ishii E, et al. Breakage and sensitive Cis-spliced fusion RNAs between adjacent genes in
fusion of the TEL (ETV6) gene in immature B lymphocytes human prostate cells. PLoS Genet. 2015;11:e1005001.
induced by apoptogenic signals. Blood. 2001;97:737-743. doi: 10.1371/journal.pgen.1005001
doi: 10.1182/blood.v97.3.737 38. Kumar-Sinha C, Kalyana-Sundaram S, Chinnaiyan AM.
27. Mani RS, Tomlins SA, Callahan K, et al. Induced SLC45A3-ELK4 chimera in prostate cancer: Spotlight on
chromosomal proximity and gene fusions in prostate cancer. cis-splicing. Cancer Discov. 2012;2:582-585.
Science. 2009;326:1230-1230. doi: 10.1158/2159-8290.CD-12-0212
doi: 10.1126/science.1178124 39. Rickman DS, Pflueger D, Moss B, et al. SLC45A3-ELK4
28. Jividen K, Li H. Chimeric RNAs generated by intergenic is a novel and frequent erythroblast transformation-
splicing in normal and cancer cells. Genes Chromosomes specific fusion transcript in prostate cancer. Cancer Res.
Cancer. 2014;53:963-971. 2009;69:2734-2738.
doi: 10.1002/gcc.22207 doi: 10.1158/0008-5472.CAN-08-4926
29. Wang K, Ubriaco G, Sutherland LC. RBM6-RBM5 40. Wu CS, Yu CY, Chuang CY, et al. Integrative transcriptome
transcription-induced chimeras are differentially expressed sequencing identifies trans-splicing events with important
in tumours. BMC Genomics. 2007;8:348. roles in human embryonic stem cell pluripotency. Genome
Res. 2014;24:25-36.
30. Parra G, Reymond A, Dabbouseh N, et al. Tandem
chimerism as a means to increase protein complexity in the doi: 10.1101/gr.159483.113
human genome. Genome Res. 2006;16:37-44. 41. Murphy L, Dotzlaw H, Hamerton J, Schwarz J. Investigation
doi: 10.1101/gr.4145906 of the origin of variant, truncated estrogen receptor-like
mRNAs identified in some human breast cancer biopsy
31. Denoeud F, Kapranov P, Ucla C, et al. Prominent use of samples. Breast Cancer Res Treat. 1993;26:149-161.
distal 5′ transcription start sites and discovery of a large
number of additional exons in ENCODE regions. Genome doi: 10.1007/BF00689688
Res. 2007;17:746-759. 42. Pink J, Fritsch M, Bilimoria M, Assikis V, Jordan V. Cloning
doi: 10.1101/gr.5660607 and characterization of a 77-kDa oestrogen receptor
isolated from a human breast cancer cell line. Br J Cancer.
32. Siepel A, Diekhans M, Brejová B, et al. Targeted discovery of 1997;75:17-27.
novel human exons by comparative genomics. Genome Res.
2007;17:1763-1773. doi: 10.1038/bjc.1997.4
doi: 10.1101/gr.7128207 43. Li H, Wang J, Mor G, Sklar J. A neoplastic gene fusion
mimics trans-splicing of RNAs in normal human cells.
33. Kannan K, Wang L, Wang J, Ittmann MM, Li W, Yen L. Science. 2008;321:1357-1361.
Recurrent chimeric RNAs enriched in human prostate
cancer identified by deep sequencing. Proc Natl Acad Sci U S doi: 10.1126/science.1156725
A. 2011;108:9172-9177. 44. Yuan H, Qin F, Movassagh H, et al. A chimeric RNA
doi: 10.1073/pnas.1100489108 characteristic of rhabdomyosarcoma in normal myogenesis
process. Cancer Discov. 2013;3:1394-1403.
34. Nacu S, Yuan W, Kan Z, et al. Deep RNA sequencing
analysis of readthrough gene fusions in human prostate doi: 10.1158/2159-8290.CD-13-0186
adenocarcinoma and reference samples. BMC Med 45. Sutton RE, Boothroyd JC. Evidence for trans splicing in
Genomics. 2011;4:1-22. trypanosomes. Cell. 1986;47:527-535.
doi: 10.1186/1755-8794-4-11 doi: 10.1016/0092-8674(86)90617-3
Volume 4 Issue 1 (2025) 14 doi: 10.36922/gpd.3641

