Page 29 - GTM-2-3

Global Translational Medicine Critical roles for BRD4 identified in cancer

Ethics approval and consent to participate 10. Wu SY, Chiang CM, 2007, The double bromodomain-
containing chromatin adaptor Brd4 and transcriptional
Not applicable. regulation. J Biol Chem, 282: 13141–13145.
Consent for publication https://doi.org/10.1074/jbc.R700001200

Not applicable. 11. Devaiah BN, Gegonne A, Singer DS, 2016, Bromodomain 4:
A cellular Swiss army knife. J Leukoc Biol, 100: 679–686.
Availability of data https://doi.org/10.1189/jlb.2RI0616-250R

Not applicable. 12. Devaiah BN, Case-Borden C, Gegonne A, et al., 2016, BRD4
is a histone acetyltransferase that evicts nucleosomes from
References chromatin. Nat Struct Mol Biol, 23: 540–548.
1. Deeney JT, Belkina AC, Shirihai OS, et al., 2016, BET https://doi.org/10.1038/nsmb.3228
bromodomain proteins Brd2, Brd3 and Brd4 selectively 13. Malvezzi F, Stubbs CJ, Jowitt TA, et al., 2021, Phosphorylation-
regulate metabolic pathways in the pancreatic β-cell. PLoS dependent BRD4 dimerization and implications for
One, 11: e0151329.
therapeutic inhibition of BET family proteins. Commun
https://doi.org/10.1371/journal.pone.0151329 Biol, 4: 1273.
2. Marazzi I, Greenbaum BD, Low DH, et al., 2018, Chromatin https://doi.org/10.1038/s42003-021-02750-6
dependencies in cancer and inflammation. Nat Rev Mol Cell 14. Devaiah BN, Mu J, Akman B, et al., 2020, MYC protein
Biol, 19: 245–261.
stability is negatively regulated by BRD4. Proc Natl Acad Sci
https://doi.org/10.1038/nrm.2017.11 U S A, 117: 13457–13467.
3. Jones MH, Numata M, Shimane M, 1997, Identification https://doi.org/10.1073/pnas.1919507117
and characterization of BRDT: A testis-specific gene related 15. Dey A, Ellenberg J, Farina A, et al., 2000, A bromodomain
to the bromodomain genes RING3 and Drosophila fsh. protein, MCAP, associates with mitotic chromosomes and
Genomics, 45: 529–534.
affects G(2)-to-M transition. Mol Cell Biol, 20: 6537–6549.
https://doi.org/10.1006/geno.1997.5000
https://doi.org/10.1128/MCB.20.17.6537-6549.2000
4. Shang E, Nickerson HD, Wen D, et al., 2007, The first 16. Dey A, Nishiyama A, Karpova T, et al., 2009, Brd4 Marks
bromodomain of Brdt, a testis-specific member of the BET select genes on mitotic chromatin and directs Postmitotic
sub-family of double-bromodomain-containing proteins, transcription. Mol Biol Cell, 20: 4899–4909.
is essential for male germ cell differentiation. Development,
134: 3507–3515. https://doi.org/10.1091/mbc.e09-05-0380
https://doi.org/10.1242/dev.004481 17. Mochizuki K, Nishiyama A, Jang MK, et al., 2008,
The bromodomain protein Brd4 stimulates G1 gene
5. Zhou Q, Li T, Price DH, 2012, RNA polymerase II elongation transcription and promotes progression to S phase. J Biol
control. Annu Rev Biochem, 81: 119–143.
Chem, 283: 9040–9048.
https://doi.org/10.1146/annurev-biochem-052610-095910
https://doi.org/10.1074/jbc.M707603200
6. French CA, 2016, Small-molecule targeting of BET proteins 18. Yang ZY, He N, Zhou Q, 2008, Brd4 recruits P-TEFb to
in cancer. Adv Cancer Res, 131: 21–58.
chromosomes at late mitosis to promote G1 gene expression
https://doi.org/10.1016/bs.acr.2016.04.001 and cell cycle progression. Mol Cell Biol, 28: 967–976.
7. Liu Z, Wang P, Chen H, et al., 2017, Drug discovery targeting https://doi.org/10.1128/MCB.01020-07
bromodomain-containing protein 4. J Med Chem, 60: 4533– 19. Di Micco R, Fontanals-Cirera B, Low V, et al., 2014, Control
4558.
of embryonic stem cell identity by BRD4-dependent
https://doi.org/10.1021/acs.jmedchem.6b01761 transcriptional elongation of super-enhancer-associated
pluripotency genes. Cell Rep, 9: 234–247.
8. Bradner JE, Hnisz D, Young RA, 2017, Transcriptional
addiction in cancer. Cell, 168: 629–643. https://doi.org/10.1016/j.celrep.2014.08.055
https://doi.org/10.1016/j.cell.2016.12.013 20. Liu W, Stein P, Cheng X, et al., 2014, BRD4 regulates
Nanog expression in mouse embryonic stem cells and
9. Lori L, Pasquo A, Lori C, et al., 2016, Effect of BET missense
mutations on bromodomain function, inhibitor binding and preimplantation embryos. Cell Death Differ, 21: 1950–1660.
stability. PLoS One, 11: e0159180. https://doi.org/10.1038/cdd.2014.124
https://doi.org/10.1371/journal.pone.0159180 21. Wu T, Pinto HB, Kamikawa YF, et al., 2015, The BET

Volume 2 Issue 3 (2023) 8 https://doi.org/10.36922/gtm.1442