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Global Translational Medicine                                             Parkinson’s: From cause to cure



               Genes (Basel). 2022;13(3):471.                     Parkinson’s disease therapeutics. Expert Opin Drug Discov.
                                                                  2020;15(1):53-62.
               doi: 10.3390/GENES13030471
                                                                  doi: 10.1080/17460441.2020.1691165
            31.  Kamath T, Abdulraouf A, Burris SJ,  et al. Single-cell
               genomic profiling of human dopamine neurons identifies   41.  Fabbri M, Ferreira JJ, Rascol O. COMT Inhibitors in
               a population that selectively degenerates in Parkinson’s   the management of Parkinson’s disease.  CNS Drugs.
               disease. Nat Neurosci. 2022;25(5):588-595.         2022;36(3):261-282.
               doi: 10.1038/S41593-022-01061-1                    doi: 10.1007/S40263-021-00888-9
            32.  Demailly A, Moreau C, Devos D. Effectiveness of continuous   42.  Woitalla D, Buhmann C, Hilker-Roggendorf R, et al. Role of
               dopaminergic therapies  in Parkinson’s disease:  A  review   dopamine agonists in Parkinson’s disease therapy. J Neural
               of   L-DOPA    pharmacokinetics/pharmacodynamics.  Transm (Vienna). 2023;130(6):863-873.
               J Parkinsons Dis. 2024;14:925-939.                 doi: 10.1007/S00702-023-02647-0
               doi: 10.3233/jpd-230372                         43.  Jing XZ, Yang HJ, Taximaimaiti R, Wang XP. Advances in
            33.  Farzanehfar P, Woodrow H, Horne M. Assessment of wearing   the therapeutic use of non-ergot dopamine agonists in the
               off in Parkinson’s disease using objective measurement.   treatment of motor and non-motor symptoms of Parkinson’s
               J Neurol. 2021;268(3):914-922.                     disease. Curr Neuropharmacol. 2023;21(5):1224-1240.
               doi: 10.1007/s00415-020-10222-w                    doi: 10.2174/1570159X20666220915091022
            34.  Murakami H, Shiraishi T, Umehara T, Omoto S, Iguchi Y.   44.  Gray R, Ives N, Rick C,  et al. Long-term effectiveness of
               Recent advances in drug therapy for Parkinson’s disease.   dopamine agonists and monoamine oxidase B inhibitors
               Intern Med. 2023;62(1):33-42.                      compared with levodopa as initial treatment for Parkinson’s
                                                                  disease (PD MED): A  large, open-label, pragmatic
               doi: 10.2169/internalmedicine.8940-21              randomised trial. Lancet. 2014;384(9949):1196-1205.

            35.  LeWitt PA, Hauser RA, Pahwa R, et al. Safety and efficacy of      doi: 10.1016/S0140-6736(14)60683-8
               CVT-301 (levodopa inhalation powder) on motor function
               during off periods in patients with Parkinson’s disease:   45.  Rose EP, Osterberg VR, Gorbunova V, Unni VK. Alpha-
               A  randomised, double-blind, placebo-controlled phase 3   synuclein modulates the repair of genomic  DNA double-
               trial. Lancet Neurol. 2019;18(2):145-154.          strand breaks in a DNA-PK -regulated manner. Neurobiol
                                                                                       cs
                                                                  Dis. 2024;201:106675
               doi: 10.1016/S1474-4422(18)30405-8
                                                                  doi: 10.1016/j.nbd.2024.106675
            36.  Zou D, Liu R, Lv Y, Guo J, Zhang C, Xie Y. Latest advances
               in dual inhibitors of acetylcholinesterase and monoamine   46.  Price DL, Khan A, Angers R,  et al.  In vivo effects of the
               oxidase B against Alzheimer’s disease. J Enzyme Inhib Med   alpha-synuclein misfolding inhibitor minzasolmin supports
               Chem. 2023;38(1):2270781.                          clinical development in Parkinson’s disease. NPJ Parkinsons
                                                                  Dis. 2023;9(1):114.
               doi: 10.1080/14756366.2023.2270781
                                                                  doi: 10.1038/S41531-023-00552-7
            37.  Lv Y, Zheng Z, Liu R, Guo J, Zhang C, Xie Y. Monoamine
               oxidase B inhibitors based on natural privileged scaffolds:   47.  Hariz M, Blomstedt P. Deep brain stimulation for Parkinson’s
               A review of systematically structural modification. Int J Biol   disease. J Intern Med. 2022;292(5):764-778.
               Macromol. 2023;251:126158.                         doi: 10.1111/JOIM.13541
               doi: 10.1016/J.IJBIOMAC.2023.126158             48.  Hacker ML, Turchan M, Heusinkveld LE, et al. Deep brain

            38.  Tan YY, Jenner P, Di Chen S. Monoamine oxidase-B   stimulation  in  early-stage  Parkinson  disease:  Five-year
               inhibitors  for  the  treatment  of  Parkinson’s  disease:  Past,   outcomes. Neurology. 2020;95(4):E393-E401.
               present, and future. J Parkinsons Dis. 2022;12(2):477-493.     doi: 10.1212/WNL.0000000000009946
               doi: 10.3233/JPD-212976                         49.  Kremer NI, van Laar T, Lange SF, et al. STN-DBS electrode
            39.  Jenner P, Rocha JF, Ferreira JJ, Rascol O, Soares-da-Silva  P.   placement accuracy and motor improvement in Parkinson’s
               Redefining the strategy for the use of COMT inhibitors   disease:  Systematic  review  and individual patient meta-
               in Parkinson’s disease: The role of opicapone.  Expert Rev   analysis. J Neurol Neurosurg Psychiatry. 2023;94(3):236-244.
               Neurother. 2021;21(9):1019-1033.                   doi: 10.1136/JNNP-2022-329192
               doi: 10.1080/14737175.2021.1968298              50.  Krishna V, Fishman PS, Eisenberg HM, et al. Trial of globus
                                                                  pallidus focused ultrasound ablation in Parkinson’s disease.
            40.  Moschovou  K,  Melagraki  G,  Mavromoustakos  T,
               Zacharia   LC, Afantitis A. Cheminformatics and virtual   N Engl J Med. 2023;388(8):683-693.
               screening studies of COMT inhibitors as potential      doi: 10.1056/NEJMOA2202721


            Volume 3 Issue 4 (2024)                         11                              doi: 10.36922/gtm.5082
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