Page 115 - GTM-4-1

Global Translational Medicine AA amyloidosis in rheumatoid arthritis

(n = 127) (P = 0.213, P = 0.262, P = 0.462), including with latent (n = 2) and those with severe giAAa (n = 12)
within female (P = 0.745, P = 0.528, P = 0.593) and male (69.00 years versus 60.75 years, P = 0.048). Statistical
subgroups (P = 0.297, P = 0.521, P = 0.662). Furthermore, significance was not calculated for male patients due to the
comparisons between patients with sAAa (n = 34) and presence of a zero divisor or limited data availability.
those with giAAa (n = 31) yielded no statistically significant According to the results, amyloidosis developed in
differences (P = 0.811, P = 0.883, P = 0.867), including both sexes and at any stage during the course of the
within female (P = 0.623, P = 0.820, P = 0.861) and male disease (Tables 1 and 2). The relationships (P values of
subgroups (P = 1.00, P = 1.00, P = 1.00). correlation) between demographic characteristics, disease
No significant differences were observed in the mean onset, and disease duration among RA patients (N = 161)
age at death between patients with latent giAAa (n = 2) and with sAAa (n = 34 of 161) and without sAAa (n = 127 of
those with mild giAAa (n = 17) (P = 0.364), latent giAAa 161), between patients with sAAa (n = 34) and those with
(n = 2) and severe giAAa (n = 12) (P = 0.115), or mild giAAa giAAa (n = 31 of 34), as well as between patients with latent
(n = 17) and severe giAAa (n = 12) (P = 0.363). However, giAAa (n = 2 of 31) and mild (n = 17 of 31) or severe giAAa
the mean age at death of female patients with latent giAAa (n = 12 of 31), are summarized in Table 2.
(n = 2) was significantly higher than that of female patients
with mild giAAa (n = 17) (69.00 years versus 67.69 years, 3.2. Histological characteristics of sAAa and/or giAAa
P = 0.05). A statistically significant difference was also AA deposits in the GI tract are demonstrated in
observed between the mean age at death of female patients Figures 1 and 2.

Table 1. Demographic and clinical characteristics of 161 autopsied RA patients with systemic and gastrointestinal amyloid A
amyloidosis
Clinical and Number of Age at death Age at onset of disease Disease duration
histological diagnosis autopsies (Mean years±SD) (Mean years±SD) (Mean years±SD)
RA patients (total) 161 65.32±12.99 50.83±17.02 14.43±10.55
Female 116 64.95±11.84 50.19±15.78 14.79±10.70
Male 45 66.27±15.67 52.57±20.15 13.46±10.22
With sAAa 34 (of 161) 62.41±15.82 47.61±18.33 15.58±9.51
Female 29 64.34±11.27 48.56±15.54 15.70±10.06
Male 5 51.20±31.51 41.25±34.72 14.75±5.12
Without sAAa 127 (of 161) 66.10±12.07 51.77±16.59 14.09±10.86
Female 87 65.15±12.08 50.79±15.92 14.49±10.97
Male 40 68.15±11.94 53.94±18.05 13.30±10.71
With giAAa a 31 (of 34) 63.32±14.77 48.29±16.68 16.00±9.66
Female 26 65.65±8.25 49.46±12.62 16.21±10.29
Male 5 51.20±31.51 41.25±34.72 14.75±5.12
With latent giAAa b 2 (of 31) 69.00±2.83 66.00±0.0 5.00±0.0
Female 2 69.00±2.83 66.00±0.0 5.00±0.0
Male 0 Not applicable Not applicable Not applicable
With mild giAAa 17 (of 31) 65.59±12.00 52.31±12.19 15.38±9.67
Female 16 67.69±8.58 53.31±12.19 15.38±9.67
Male 1 32.00 Not applicable Not applicable
With severe giAAa 12 (of 31) 59.17±18.78 40.82±20.24 17.91±9.74
Female 8 60.75±6.65 40.57±8.92 19.71±11.60
Male 4 56.00±34.21 41.25±34.72 14.75±5.12
Notes: Tissue blocks of the GI tract were not available in 3 of 34 patients with sAAa; In 2 of 31 GI tract tissue blocks, amyloid A deposits were not
a
b
detected histologically, and these were considered as latent-stage giAAa.
Abbreviations: giAAa: Gastrointestinal amyloid A amyloidosis; RA: Rheumatoid arthritis; sAAa: Systemic amyloid A amyloidosis; SD: Standard
deviation; GI: Gastrointestinal.

Volume 4 Issue 1 (2025) 107 doi: 10.36922/gtm.5325