Page 96 - GTM-4-1

Global Translational Medicine Brain morphology in obesity

rats on the high-fat diet but not in females. In a study Writing – review & editing: Tatyana A. Mityukova, Tatyana
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by Li et al., investigating the effects of a maternal high- E. Kuznetsova, Anastasia A. Basalai, Olga Y. Poluliakh
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fat diet on offspring, male offspring showed significant
metabolic abnormalities, whereas female offspring showed Ethics approval and consent to participate
only a slight increase in body weight and did not develop This study was approved by the Bioethics Committee of the
the metabolic abnormalities observed in males. Carrillo Institute of Physiology of the National Academy of Sciences
et al. studied the effects of estradiol during the early of Belarus (protocols No.:1 on January 22, 2021, and No.:2
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postnatal period on brain metabolic changes induced by on February 2, 2022) and conducted in accordance with
overeating. Neonatal estradiol treatment restored body the guidelines set forth by the European Convention for
weight and subcutaneous fat to control levels in males the Protection of Vertebrate Animals (ETS No. 123).
fed a high-fat diet. In females, however, such exposure
affected hypothalamic neuropeptides without changing Consent for publication
body weight. The authors concluded that increasing Not applicable.
estradiol levels during the neonatal period could induce
different metabolic shifts in males and females, with Availability of data
estradiol preventing the adverse effects of overeating in
males. Based on our data, we hypothesize that female rats The datasets used and/or analyzed during the present
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are more protected than males from psycho-emotional study are available from the Institute of Physiology of the
disorders, particularly depression, caused by obesity. National Academy of Sciences of Belarus, upon reasonable
and justifiable request in accordance with the rules and
5. Conclusion procedures of the Institute of Physiology of the National

The comparison of the effects of a HCD on male and female Academy of Sciences of Belarus (https://physiology.by/or
rats reveals sex-specific changes in glial cells and peculiarities biblio@fizio.bas-net.by).
of neurodegenerative processes in the PFC. Comparable References
manifestations of neurodegenerative processes are observed
in most hippocampal regions in both male and female 1. Badre D, Kayser AS, D’Esposito M. Frontal cortex and the
rats. However, proinflammatory and neurodegenerative discovery of abstract action rules. Neuron. 2010;66(2):315-326.
processes in the brain regions studied are associated with doi: 10.1016/j.neuron.2010.03.025
depression only in male rats, not in female rats. 2. Yang Y, Raine A. Prefrontal structural and functional brain

Acknowledgments imaging findings in antisocial, violent, and psychopathic
individuals: A meta-analysis. Psychiatry Res. 2009;174(2):81-88.
None. doi: 10.1016/j.pscychresns.2009.03.012

Funding 3. Li Y, Shen M, Stockton ME, Zhao X. Hippocampal deficits
in neurodevelopmental disorders. Neurobiol Learn Mem.
The work was supported by the State Program for Scientific 2019;165:106945.
Research (No.:4.1.1.5) of the National Academy of Sciences
of Belarus. doi: 10.1016/j.nlm.2018.10.001
4. Giel KE, Hartmann A, Zeeck A, et al. Decreased emotional
Conflict of interest perception in obesity. Eur Eat Disord Rev. 2016;24(4):341-346.
The authors declare that they have no competing interests. doi: 10.1002/erv.2444

Author contributions 5. Blasco BV, García-Jiménez J, Bodoano I, Gutiérrez-Rojas L.
Obesity and depression: Its prevalence and influence as a
Conceptualization: Tatyana A. Mityukova prognostic factor: A systematic review. Psychiatry Investig.
Formal analysis: Tatyana E. Kuznetsova, Anastasia A. 2020;17(8):715-724.
Basalai, Olga Y. Poluliakh doi: 10.30773/pi.2020.0099
Investigation: Tatyana E. Kuznetsova, Anastasia A. Basalai, 6. Mabrok HB, Ramadan AA, Hamed IM, Mohamed DA.
Olga Y. Poluliakh Obesity as inducer of cognitive function decline via dysbiosis
Methodology: Tatyana A. Mityukova, Tatyana E. of gut microbiota in rats. Brain Sci. 2024;14(8):807.
Kuznetsova, Anastasia A. Basalai, Olga Y. Poluliakh
Writing – original draft: Tatyana A. Mityukova, Tatyana E. doi: 10.3390/brainsci14080807
Kuznetsova 7. Bocarsly ME, Fasolino M, Kane GA, et al. Obesity

Volume 4 Issue 1 (2025) 88 doi: 10.36922/gtm.5000