Page 329 - IJB-10-1

International Journal of Bioprinting 3D-bioprinted meningioma model

cancer cells revealed that under 3D cultivation conditions, Conflict of interest
these cells exhibit significantly higher tumorigenicity
than those under 2D conditions. Similarly, our findings The authors declare no conflicts of interest.
36
demonstrate that it was easier for IOMM-Lee cells grown Author contributions
in a 3D environment to form subcutaneous tumors
in nude mice than those grown in a 2D environment. Conceptualization: Peng Chen, Yongan Jiang, Jianwei
Furthermore, researchers have discovered that tumor Chen, Shiqi Cheng, Yan Zhang
cells grown under 3D conditions possess a higher level of Data acquisition: Peng Chen, Yongan Jiang, Jianwei Chen,
resistance to chemotherapy and an increased capacity for Fan Xu
immune evasion, further emphasizing 3D cultivation as a Formal analysis: Peng Chen, Jianwei Chen, Fan Xu, Raorao
more accurate and reliable method for evaluating tumor Yuan
cell tumorigenicity. These findings can help improve Funding acquisition: Shiqi Cheng, Yan Zhang
37
the study of tumor development and treatment, thereby Investigation: Peng Chen, Yongan Jiang, Hengyi Fan,
providing a more solid foundation for research on the Jianwei Chen
efficacy of anticancer drugs and cancer prevention. Resources: Fan Xu, Shiqi Cheng, Yan Zhang
Supervision: Yan Zhang
5. Conclusion Writing – original draft: Peng Chen, Yongan Jiang, Hengyi

In summary, our study confirms that 3D-printed microtissue Fan
models can simulate the actual in vivo environment of Writing – review & editing: Peng Chen, Yongan Jiang,
cancer cells, creating near-realistic survival conditions that Hengyi Fan
better facilitate the recovery of cancer cell traits in vitro.
Our findings demonstrate that 3D-bioprinted microtissue Ethics approval and consent to participate
models provide a superior research platform for the study This study was granted permission for the use of
of tumor cell proliferation, development, invasion, tumor experimental animals by the Ethics Committee of
occurrence, drug sensitivity, and prognosis in the human Nanchang University (SYXK(G) 2021-0004).
body. The malignant meningioma model presented in
this study is a valuable tool for more in-depth research on Consent for publication
malignant meningioma. However, this in vitro model is
structurally different to the complex biological systems Not applicable.
within the human body. For instance, in vitro models lack
the interactions between IOMM-Lee cells and surrounding Availability of data
nerve cells and ECM, while subcutaneous tumor models The data from these studies are available from the
and intracranial tumor environments also exhibit variations. corresponding author, Dr. Yan Zhang, upon reasonable
Therefore, more validation and comparative studies are request.
needed to prove the accuracy and reliability of this system in
predicting tumor cell behavior and drug sensitivity. References

Acknowledgments 1. Cao J, Yan W, Li G, Zhan Z, Hong X, Yan H. Incidence and
survival of benign, borderline, and malignant meningioma
We acknowledge the technical assistance of Dr. XiuXiu patients in the United States from 2004 to 2018. Int J Cancer.
Zhang and Dr. ZiXian Wang from the Precision Medicine 2022;151(11):1874-1888.
and Healthcare Research Center, Tsinghua-Berkeley doi: 10.1002/ijc.34198
Shenzhen Institute (TBSI), Tsinghua University.
2. Dolecek TA, Dressler EVM, Thakkar JP, Liu M, Al-Qaisi
Funding A, Villano JL. Epidemiology of meningiomas post-Public
Law 107-206: The Benign Brain Tumor Cancer Registries
This research was supported by the National Natural Amendment Act. Cancer. 2015;121(14):2400-2410.
Science Foundation (Grant Nos. 82260378 and 82260388), doi: 10.1002/cncr.29379
Natural Science Foundation of Jiangxi Province (Grant Nos. 3. Schaff LR, Mellinghoff IK. Glioblastoma and other
20201BBG71007 and 20212BAB216053), and Traditional primary brain malignancies in adults: A review. JAMA.
Chinese Medicine Foundation of Jiangxi Province (Grant 2023;329(7):574-587.
No. 2022Z017). doi: 10.1001/jama.2023.0023

Volume 10 Issue 1 (2024) 321 https://doi.org/10.36922/ijb.1342