Page 377 - IJB-10-1

International

Journal of Bioprinting

RESEARCH ARTICLE
Design of biomedical gradient porous scaffold

via a minimal surface dual-unit continuous
transition connection strategy

Yuting Lv , Zheng Shi , Binghao Wang *, Miao Luo , Xing Ouyang ,
1
1,2
3,4
1
3
Jia Liu *, Hao Dong , Yanlei Sun , and Liqiang Wang *
3,4
1
2,5
1
1 College of Mechanical and Electronic Engineering, Shandong University of Science and Technology,
Qingdao, Shandong, China
2 State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, China
3 Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China
4 Guangxi Key Laboratory of Basic and Translational Research of Bone and Joint Degenerative
Diseases, Baise, Guangxi, China
5 National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China
Abstract
In this work, a series of new gradient porous scaffolds were innovatively designed via
a dual-unit continuous transition connection strategy based on the minimal surface
structures (primitive [P], diamond [D], and gyroid [G]). The scaffolds were successfully
*Corresponding authors: prepared through selective laser melting technology. The results showed that the
Binghao Wang
(wang_binghao@ymun.edu.cn) dual-unit continuous transition connection strategy significantly improved the
Jia Liu mechanical properties of the connected scaffolds. The compression strength of
(liujia0111@live.cn) the scaffolds was found to be (P-G)>(P-D)>(G-P)>(G-D)>(D-G)>(D-P), with the P-G
Liqiang Wang structure exhibiting a compression strength of 167.7 MPa and an elastic modulus of
(wang_liqiang@sjtu.edu.cn) 3.3 GPa. The mechanical properties of the porous scaffolds were primarily influenced
Citation: Lv Y, Shi Z, Wang B, by the outer unit type, the connection condition between different units, the unit
et al. Design of biomedical gradient size, and the porosity. Scaffolds with the outer P unit demonstrated better mechanical
porous scaffold via a minimal
surface dual-unit continuous properties due to the higher mechanical strength of the P structure. The connection
transition connection strategy. Int J performance between different units varied, with P and G units forming a good
Bioprint. 2024;10(1):1263. continuous transition connection, while the connection performance between P and
doi: 10.36922/ijb.1263
D units was the weakest. The dual-unit continuous transition connection strategy
Received: July 6, 2023 offers a promising approach to optimize the connection performance of different
Accepted: September 11, 2023 units, providing new insights into the design of medical porous scaffolds.
Published Online: January 8, 2024
Copyright: © 2024 Author(s).
This is an Open Access article Keywords: Biomedical porous scaffold; Selective laser melting; Minimal surface;
distributed under the terms of the Mechanical property
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience
Publishing remains neutral with Bone defect caused by fractures, bone tumors, external trauma, and other pathologies
regard to jurisdictional claims in poses a significant challenge in clinical treatment. Globally, there are nearly 15 million
1
published maps and institutional fracture cases reported annually. Autologous bone transplantation is considered
2
affiliations.
the optimal treatment method due to its lower risk of infection; however, the limited

Volume 10 Issue 1 (2024) 369 https://doi.org/10.36922/ijb.1263