Page 64 - IJB-10-1

International Journal of Bioprinting Microfluidic-assisted 3D bioprinting

Table 1. Summary of different technologies used to produce biocompatible fibers, even cell-laden, presenting different morphologies
and material compositions that are produced with capillary microfluidic platforms or with a microfluidic chip

Spinning plat- In
Spinning technology Fiber type Material Crosslinking agent Cell type Ref.
form vivo
Chitosan/Polyethylene
Solid and peapod-like GTA / / 94
glycol (PEG)
PEG with maleimide
Solid DTT + TEA NIH 3T3, MC3T3 No 82
end groups (PEG-4Mal)
Glass capillary Multi-compartment,
hollow and combi- Alginate CaCl 2 / / 135
nation
Hollow Alginate/GelMA CaCl + LAP (UV-Vis) HUVECs, MC3T3-E1 No 81
2
Hollow Chitosan/Gelatin TPP NIH 3T3 No 133
Metallic needle in Hollow Gelatin/GelMA LAP (UV-Vis) in ice HUVECs No 72
a glass capillary bath
Capillary microfluid- Coaxial nozzle in Solid straight and Alginate/GelMA CaCl + LAP (UV-Vis) HUVECs No 73
ics (glass or metallic glass capillary spiral 2
connectors) NIH 3T3, C2C12,
Cardiomyocytes, HU-
Glass capillary + Core-shell Alginate/Collagen/ CaCl VEC, MS1, Nerve cell Yes 83
rotating motor Fibrinogen 2 Cortical cells, Neural
stem cells, HepG2,
MIN6m9, HeLa
Coaxial needles + Solid Alginate/GelMA CaCl + Irgacure (UV) hBM-MSCs No 78
rotating motor 2
Gelatin–hydroxy-
Solid, hollow, core- phenylpropionic acid HRP/H O MDCK, NIH 3T3 No 75
Triple-orifice shell (Gtn-HPA) 2 2
coaxial needles
Solid, hollow, core- Gtn-HPA, NIPAAM, 84
shell Alginate HRP/H O + CaCl 2 / /
2
2
Solid, hollow, with oil 3
droplets Gellan gum CaCl 2 / /
From thin flat to Alginate CaCl in IPA / / 203
cylindrical 2
Multi-compartment Alginate/PVA CaCl / / 74
and multi-hollows 2
PDMS chip
Solid Alginate CaCl / Yes 204
2
NCI-H1650, HU-
Multi-compartment Alginate CaCl No 132
2 VECs, HFL1
Core-shell with micro- Alginate/PGA BaCl NIH 3T3 and A549 No 205
passage 2
Microfluidic devices
(without glass or me- Solid Alginate/PEGDA CaCl + Irgacure (UV) / / 89
2
tallic connectors) PDMS chip + Flat stripe-patterned Alginate/PGA BaCl 2 HepG2, Swiss 3T3 No 117
rotating motor
Grooved Alginate/GelMA CaCl + Irgacure (UV) C2C12 No 88
2
Syringe and PDMS 90
chip Solid, Solid patterned GelMA Irgacure (UV) C2C12 No
PC chip + rotating PEG-fibrinogen/ CaCl + Irgacure (UV) 63
2
motor Solid alginate + thrombin nLacZ- (Mabs) Yes
Solid, hollow, core-
PMMA/COC chip shell, multiple core- PEGDMA/ GelMA Irgacure (UV) / / 91
shell
Biocompatible Core-shell with differ- Fibrinogen, alginate CaCl C2C12 No 139
resin ent core materials 2

Volume 10 Issue 1 (2024) 56 https://doi.org/10.36922/ijb.1404