Page 83 - IJB-10-1

International

Journal of Bioprinting

REVIEW ARTICLE
Three-dimensional bioprinting for

musculoskeletal regeneration and disease
modeling

Qiang Wei , Yuhao Peng , Weicheng Chen , Yudong Duan , Genglei Chu ,
1
1
1
1†
1†
Jie Hu , Shujun Lyu , Zhigang Chen *, Fengxuan Han *, and Bin Li *
2
2
1
1
1
1 Medical 3D Printing Center, Orthopaedic Institute, Department of Orthopaedic Surgery,
The First Affiliated Hospital, School of Biology and Basic Medical Sciences, Suzhou Medical
College, Soochow University, Suzhou 215006, China
2 Department of Orthopaedic Surgery, The Affiliated Hai’an Hospital of Nantong University, Hai’an,
Nantong 226600, China
(This article belongs to the Special Issue: The Latest Advances of Bioinks for 3D Bioprinting)
Abstract
Musculoskeletal disease and injury are highly prevalent disorders that impose
tremendous medical and socioeconomic burdens. Tissue engineering has
attracted increasing attention as a promising technique of regenerative
medicine to restore degenerative or damaged tissues and is used to produce
† These authors contributed functional disease models. As a revolutionary technology, three-dimensional
equally to this work. (3D) bioprinting has demonstrated a considerable potential in enhancing the
*Corresponding authors: versatility of tissue engineering. 3D bioprinting allows for the rapid and accurate
Zhigang Chen spatial patterning of cells, growth factors, and biomaterials to generate biomimetic
(chenzhigang1976@ntu.edu.cn) tissue constructs. Meanwhile, 3D-bioprinted in vitro models also offer a viable
Fengxuan Han
(fxhan@suda.edu.cn) option to enable precise pharmacological interventions in various diseases.
Bin Li This review provides an overview of 3D bioprinting methods and bioinks for
(binli@suda.edu.cn) therapeutic applications and describes their potential for musculoskeletal tissue
regeneration. We also highlight the fabrication of 3D-bioprinted models for drug
Citation: Wei Q, Peng Y, Chen W,
et al. Three-dimensional bioprinting development targeting musculoskeletal disease. Finally, the existing challenges
for musculoskeletal regeneration and future perspectives of 3D bioprinting for musculoskeletal regeneration and
and disease modeling. Int J Bioprint. disease modeling are discussed.
2024;10(1):1037.
doi: 10.36922/ijb.1037
Received: June 03, 2023 Keywords: 3D bioprinting; Bioink; Musculoskeletal tissue; Regeneration; Disease
Accepted: July 31, 2023 modeling
Published Online: January 2, 2024
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, The musculoskeletal system is made of bone, skeletal muscle, cartilage, tendon, meniscus,
provided the original work is and intervertebral disc (IVD), which are responsible for motion as well as provide
properly cited. structural support for the human body and protect internal organs. In daily activities,
Publisher’s Note: AccScience musculoskeletal tissues are susceptible to small tears or other injuries due to various
Publishing remains neutral with mechanical loads. Unlike cartilage, tendon, meniscus, and IVD, bone and skeletal muscle
regard to jurisdictional claims in
published maps and institutional have high regenerative capacity after slight injuries. However, severe damage beyond the
affiliations. self-repair ability can lead to a range of musculoskeletal disorders (MSDs).

Volume 10 Issue 1 (2024) 75 https://doi.org/10.36922/ijb.1037