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International Journal of Bioprinting Kidney hydrogel print for renal cancer model

Figure 3. Extrusion printing of complicated structures using various concentrations of GelMA-Kidney bioink.

P2RX6, ADIRF-AS1, and SGK2 (Figure 5A), were found to category: cell–cell interactions, cellular growth, and cellular
be significantly upregulated in response to stimulation by migration. The cells were also found to be enriched with GO
kidney dECM. terms involved in the cellular component category, such as
Additionally, GO enrichment analysis was performed basement membrane and extracellular region, indicating
using RNAseq results to study the changes in genes that ACHN cells under the stimulation of kidney dECM
implicated in the molecular functioning, biological could facilitate ECM remodeling. Separately, enriched GO
processes, and cellular components of ACHN cells (Figure terms involved in molecular functions included collagen
5B). ACHN cells in 10% GelMA-2% Kidney sample were binding, laminin binding, fibronectin binding, and integrin
found to be enriched with GO terms involved in the binding, suggesting that the presence of dECM facilitated
following specific terms within the biological process the cell–matrix binding process.

Volume 10 Issue 2 (2024) 287 doi: 10.36922/ijb.1413