Page 334 - IJB-10-2

International Journal of Bioprinting Continuous gradient TPMS bone scaffold

better simulating the real human femur and facilitating
bone repair.
Comparing the stress–strain curves of the three
optimized models, their shapes align with classical plastic
deformation curves. The experimental and simulation
results for stress–strain comparison demonstrate good
agreement. The simulation error for yield strength is
found to be 4.2%, verifying the accuracy of the simulation
results. Figures 16 and 17 depict a comparison of the
mechanical properties and permeability of the three
optimized models. Based on these results, it can be
concluded that G_4x12 exhibits superior mechanical
properties and permeability compared to the other two
models. Therefore, it is selected as the bone scaffold
Figure 17. Comparison of optimized structure permeability. structure model.

suitable for simulating the structure of the human femur. 5. Expected applications
Furthermore, due to the extensive surface area of the G
surface, these models enable full contact between cells In order to create bone implants suitable for human
or nutrient solution and the bone during bone repair. By bone tissue, the G_4x12 model was optimized with good
controlling the periodic parameters, the obtained topology biomechanical properties and permeability. The final bone
optimization models replicate the changes in pore size implant was manufactured using additive manufacturing.
observed in human femoral cancellous bone, thereby The specific process is as follows:

Figure 18. Design and manufacturing process of human femoral implants.

Volume 10 Issue 2 (2024) 326 doi: 10.36922/ijb.2306